Select Committee on Defence Minutes of Evidence


Memorandum submitted by Professor Malcolm Hooper, Scientific Advisor to the Gulf Veterans' Association

ACTION—NOW AND IN THE FUTURE

IMMEDIATE ACTIONS

1.  An International Conference

  This would allow a full examination of all the science completed and planned. It would enable UK scientists to meet with those from the USA and elsewhere and debate all the issues.

  I have already suggested such a Conference to the Gulf Support Group but so far no decision has been made.

2.  A Public Enquiry

  This would

    (a)  Allow a full examination of all the facts which are now available.

    (b)  Give the GWVs and their organisations a hearing.

    (c)  Require information that is hidden to emerge.

    (d)  Provide a sound basis for a new relationship between the MOD, Government and the GWVs.

  Such an Enquiry has been requested by the Royal British Legion and the Gulf Support Group as well as GWVs and their organisations.

  It has been refused. "There are not sufficient grounds for an Enquiry".

  What is provided here makes it clear that such grounds do exist and have been ignored, belittled, misunderstood, and misrepresented by the Government and MOD.

3.  Immediate programmes of research must be commenced where the present evidence is strong

    (a)  Measurement of DU in GWVs and in important organs from autopsies.

    (b)  An investigation of the immunological status of Sick Veterans.

    (c)  Sleep studies.

    (d)  SPECT and MRI scans.

    (e)  Use of new diagnostic procedures.

    (f)  Others identified from the International Conference of scientists.

4.  The MOD must become pro-active in assessing and exploring new information that has been produced in the diagnosis and treatment of GWI/S

MOD, INDEPENDENT PANEL, MAP, AND RESEARCH PROGRAMMES

MOD CONFERENCE 10 DECEMBER 1998

  This meeting was organised by Colonel John Graham of the Ministry of Defence, who is presently in Washington as the link person between the MoD, the Department of Defence, DOD, Veterans, Administration, VA, and other USA Government Agencies.

  It was the first open meeting on Gulf Health organised in the UK. As far as I was able to judge those attending were drawn mainly from the Military Medical Establishments in the States and the UK. Other interested people were there including some Gulf Veterans and members of the Press and Media.

  No speakers known to question and criticise the current views espoused by the MOD, DOD, VA were invited/agreed to participate in the Conference.

  These include,

    —  USA Senators and Members of the House of Representatives who have convened Committees whose reports have been extremely critical and sometimes damning of the role of the DOD and VA; Shays, Reigle, and Burton Reports.

    —  Scientists who have produced many peer reviewed papers on Gulf War Illness(es), GWI, and proposed very different understandings of it; Robert Haley, Garth Nicholson, Katherine Murray Leisure, Howard Urnovitz, Bill Baumzweiger, Bill Rea, Jim Tuite and others from the USA, and Goran Jamal, 1998; Christine Gosden, 1999; Shattock, Waring, and others from the UK.

    —  The Conference was therefore very unbalanced in addressing all the issues of Gulf Health. The more so because the only UK presentations, the King's Study (Simon Wessley funded by the DOD), The Manchester Study (Nicola Cherry and Gary McFarlane, funded by the MRC) and Reproductive Outcomes Study (Patricia Doyle and Noreen Maconochie, funded by the MRC) had no results for public presentation.

    —  Dr Bernadette Guldager from Denmark was the exception. She presented data on 700 Danish Gulf Veterans. This recent data was the only new information derived from the meeting.

  The Conference was largely a sham and in line with the behaviour of MOD towards GWS/I.

THE INDEPENDENT PANEL

  This was convened in December 1997 and has met four times. It is solely concerned with providing independent assessments of MOD funded research programmes concerned with the possible interactions between vaccines and NAPS (pyridostigmine bromide).

  All its work is involved with animal studies, mice, guinea pigs and marmosets.

  The guinea pig work has now been abandoned and the mouse work still remains to be done and the marmoset work will not be completed until 2003.

  Any work addressing

    (a)  The health of the current GWVs;

    (b)  diagnosis;

    (c)  treatment;

has been ruled outside the terms of reference of the Panel.

  The panel provide an alibi for taking no effective action to help current GWVs. It is part of the official unwillingness to face the unpalatable truths of the Gulf War and to offer a proper justice to the GWVs. It is a smokescreen and cover-up!

MAP (Medical Assessment Programme)

  This was established in October 1993.

  A paper was published in the BMJ (Coker et al., 1999) on the first 1,000 cases. It is, by its own admission, deeply flawed.

    (a)  The programme was not designed as a research tool;

    (b)  Clinical diagnoses were made by 17 different consultants;

    (c)  Two different disease classifications were used, both differed from that used in the USA thereby making comparisons at best approximate;

    (d)  No denominator or comparison data was available;

    (e)  Psychiatric assessment was abandoned half way through the programme in 1995 after only 255/1,000 had seen a psychiatrist;

    (f)  Follow-up was inadequate in one in five psychiatric cases;

    (g)  "Nor do we have all the results of psychiatric assessments that we advised should take place."

  There has been two changes of leadership and, as yet, no clinical audit.

  The following are notes made at a MAP presentation to the Independent Panel by Professor Harry Lee on 29 March 1999.

  It was emphasised that

    (1)  "GWVs came to MAP very worried and needed mainly reassurance in the face of their worries. When this was provided, by listening, the GWVs went away much happier." Only about half had any illness, which was described as PTSD. [In conversation, "paranoia was the most outstanding symptom"];

    (2)  MAP is not there to treat Gulf illness;

    (3)  Depleted uranium ammunition was described as "not dangerous". This is only part of the truth;

    (4)  History taking followed by examination and any investigations thought necessary on medical grounds revealed "nothing unusual";

    (5)  The spraying of organophosphate and other insecticides was stated to have been carried out with meticulous attention to the health and safety regulations and was not excessive;

    (6)  Vaccines were said to have been given according to the proper protocols and the regimen was not compressed;

    (7)  Oil fires were said to pose no pollutant problems;

    (8)  Any illness arising more than two years after the Gulf War was not attributable to service in the Gulf;

    (9)  He selectively used the report by Unwin et al in The Lancet to suggest that GWVs were no more ill than other war veterans. The other conclusions, which stated that GWVs reported two to three times more illness and that such reports were vaccine associated, were not addressed;

    (10)  There is no sensible rationale for treatment. No consideration was given to possible treatments other than doxycycline study;

    (11)  The War Pensions Agency was described as generous in its treatment of GWVs;

    (12)  Small groups of disaffected activists who agitate and seek publicity driven research programmes were presented as unredeemable trouble makers!

  Subsequently one GWV was completely misled about DU testing see section on DU above.

  This is the evidence on which the GWVs lost faith in MAP.

MOD RESEARCH PROGRAMMES

1.  The Wessley Study

  This study commenced in 1997 and the paper was published in January 1999 (Unwin et al, 1999). It was funded by the DOD!

  It was a questionnaire study in which no veterans were seen by a clinician.

2.  The Manchester Study

  This is led by Professor Nicola Cherry and funded by the MoD through the MRC. It involves yet another questionnaire, survey of mortality rates. It has not yet reported.

3.  The London Study

  This is led by Dr Patricia Doyle of the London School of Hygiene and Tropical Medicine and funded like the Manchester study. It is yet another questionnaire study which, very ambitiously, seeks to contact all GWVs in order to evaluate important questions about reproduction and birth defects.

4.  Neurological Studies

  These are an extension of the Wessley study and the first clinical assessment of GWVs. The study has just started almost 10 years after the end of the war.

  We already have extensive studies from the USA, Fukuda, 1997, Iowa study, 1997 which answer the question of incidence of symptoms and mortality, Kang, 1996. All are increased in GWVs.

  Haley, 1997, 1999, has carried out a number of neurological investigations. In this country Goran Jamal has reported important findings which have been ignored, Jamal 1998.

  It is not unfair to conclude that the UK is running round the same track as the Americans but several laps behind. We appear to have learned nothing from their studies.

CONCLUSIONS

    (1)  MAP lost the trust of the GWVs by its uncaring and arrogant attidude. Some veterans have been misled by promises made which were not fulfilled.

    (2)  The MoD Panel is an alibi for inaction.

    (3)  Nothing has been learned from the extensive American studies and investigations.

    (4)  There appears to have been a deliberate conspiracy to avoid any open debate in the scientific community and the MOD about the issues of GWS/I.

    (5)  The UK research studies started very late, and only involved questionnaires or a literature review. Another alibi for inaction.

    (6)  Some important research in the UK has not been followed up.

 REFERENCES

  Abou-Donia MB, Wilmarth K R, Jensen K F, Oehme F W, Kurt T L. Neurotoxicity resulting from coexposure to pyridostigmine Bromide, DEET, and Permethrin: Implications of Gulf War Chemical Exposures. J Toxicol environ Health 1996, 48, 35-56.

  Ader et al Psychoneuroimmunology, 2nd Edition, ed Robert Ader, David L Felten and Nicholas Cohen, Academic Press, New York 1991.

  American Forces Press Service. A New Smallpox Vaccine. 2 December 1999.

  Anon, British National Formulary, The Pharmaceutical Press, Oxford, No 32 , 1996, pp 501 ff.

  Ashford AN and Miller CS. Chemical Exposures: Low Levels and High Stakes, Van Nostrand Reinhold, New York, 1991.

  Baumzweiger, W. Brainstem-Limbic Immune Dysregulation in 111 Gulf War Vererans. A Clinical Evaluation of its Etiology, Diagnosis and Response to Headache. Int J Med 1998, 1, 129-143. Unpublished data presented at National Gulf War Resource Center, 3rd Annual Gulf War Veterans' Illnesses Conference, Arlington, VA, 18-21 September 1998.

  Bertell R in Depleted Uranium: A Post-War Disaster for the Environment and Health, Laka Foundation, May 1999, Gulf War Veterans and Depleted Uranium, pp 18-27.

  Bertell R. Gulf War Veterans and Depleted Uranium, Hague Peace Conference, May 1999.

  Bertell R. Internal Bone Seeking Radionuclides and Monocyte Counts. International Perspectives in Public Health 1993, 9, 21-25.

  Bertell R. Personal Communication.

  Booth G. Pyschodynamics of Parkinsonism Psycosomatic Medicine 1948, 10, 1-14.

  Burton, D. 2nd Report by the Committee on Government Reform and Oversight, Union Calendar No. 228. 105th Congress, 1st Session House Report 105-338, November 1997.

  Cammock L. Personal Communication.

  Chaney LA, Rockhold RW, Mozingo JR, Hume AS, Moss JI. Potentiation of Pyridostigmine Bromide toxicity in mice by selected adrenergic agents and caffeine. Vet Hum Toxicol 1997, 39, 214-9.

  Christopher CW, Cieslak MC, Pavlin JA, Eitzen EM. Biological Warfare: A Historical Perspective JAMA 1997, 278, 412-7.

  Coker WJ, Bhatt BM, Blatchley NF, Graham JT. Clinical findings for the first 1,000 Gulf War Veterans in the Ministry of Defence's Medical Assessment Programme. BMJ 1999, 318, 290-4.

  Cooney JM, Lucey JV, Dinan TG. Enhanced growth hormone responses to pyridostigmine challenge in patients with panic disorder. Br J Psychiatry, 1997, 170, 159-161.

  COTS Report. Organophosphates. Committee on the Toxicity of Chemicals in food, Consumer Products and the Environment, Woods HF Chairman, Crown copyright, 1999.

  Daily Express 19 October 1998. Article on New Plague Vaccine.

  Daily Express, 6 October 1999. Letter from John Spellar MP, MOD. Time to Listen to Science.

  Daniel GE. Analysis of a case of Neurosis with diabetes mellitus. Psychoanalytic Quarterly 1936, 5, 513-547.

  De Marinis L, Mancini A, Valle D, Fiumara C, Conte G, Bianchi A, Perrelli M, Gentilella R, Giustina A. Physiological Role of the opioid-cholinergic interaction in growth hormone neuroregulation: effect of sex and food intake. Metabolism 1997, 46, 740-4.

  Dietz LA and Military Toxics Project http://antenna.nl/wise-database/uranium/dmtp.html. This site has many contributions from a variety of authoritative sources.

  Fahey D. Case Narrative: Depleted Uranium (DU) Exposures, 1998. Available at National Gulf War Resource Center, Inc. 1224 M St, NW Washington, DC 20005, USA. http://www.gulfweb.org/ngwrc. This is a comprehensive documentation of the sources of the information on DU. It is particularly useful for its references to Military studies which have not been reported in the published literature.

  Fahey D in Depleted Uranium: A Post-War Disaster for the Environment and Health, Laka Foundation, May 1999, Depleted Uranium Weapons: Lesson from the 1991 Gulf War, pp 9-17.

  Fahey, D. Case Narrative: Depleted Uranium (DU) Exposures, 1998. Available at National Gulf War Resource Center, Inc, 1224 M St, NW Washington, DC 20005, USA. Internet: http://www.gulfweb.org/ngwrc.

  Franz DR, Jahrling PB, Friedlander AM, McClain DJ, Hoover MC, Byrne WR, Pavlin JA, Christopher MC, Eitzen EM. Clinical Recognition and Management of Patients Exposed to Biological Warfare Agents. JAMA 1997, 287, 399-411.

  Friedman A, Kaufer D, Shemer J, Hendler I, Soreq H, Tur-kaspa I. Pyridostigmine and brain penetration under stress enhances early and immediate transcriptional response. Nature Medicine, 1996, 12, 1382-5.

  Fudenberg HH. Unpublished data. Newcastle Research Group Conference "Post infectious Effects on Neural, Hormonal, Muscular and other Organ Tissues", Morpeth 11-12 November 1998 and 1999.

  Fukuda MD, Nisenbaum R, Stewart G, Thompson WW, Robin L, Washko RM, Noah DL, Barrett DH, Randall B, Herwaldt BL, Mawlw AC, Reeves WC. Chronic Multisymptom Ilnness Affecting Air Force Veterans of the Gulf War. JAMA 1998, 280, 981-988.

  Gilbert J. House of Lords, HL 3838 and 3839. Reply by Lord Gilbert, Minister of State for Defence Procurement, 19 November 1998, PQ Ref. No. 4114I/4115I.

  Glass ML, Beitner R. Effects of Carbamylcholine and Pyridostigmine on Mitochondrial-bound hexokinase in Skeletal muscle and heart. Biochem Mol Pharmacol, 1996, 57, 67-70.

  Glass ML, Chen ZM, Beitner R. Effects of carbamylcholine and Pyridostigmine on cytoskeleton-bound and cytosolic phosphofructokinase and ATP levels in different rat tissues. Gen Pharmacol, 1996, 27, 1214-6.

  Glickman LT. Weighing the Risks and Benefits of Vaccines. Adv Vet Med, 1999, 41, 701-713

  Golomb BA. Pyridostigmine Bromide. A Review of the Scientific Literature as it Pertains to Gulf War Illnesses. Rand Report Volume 2, National Defense Research Institute, 1999. Download at http://www.rand.org.

  Goodman and Gilman, The Pharmacological Basis of Therapeutics, eds Gilman AS, Goodman LS, Gilman A. Macmillan, 1980.

  Gosden C. Transcript of Testimony before USA Senate Judiciary Subcommittee on Technology, Terrorism and Government, April 1998.

  Goth's Medical Pharmacology, Ed Clark, Brater, Johnson, 12th Edition, Mosby, Toronto, 1980.

  Gray, GC, Bruce DC, Anderson CM, Kang HK, Berg PHS, Wignall FS, Knoke JD, Barrett-Connor E. The Post War Hospitalisation Experience of US Veterans of the Persian Gulf War. New Engl J Med 1996, 335, 1505-1527.

  Greenfield SA. Non-classical Actions of Cholinesterases: role in cellular differentiation, tumorigenesis and Alzheimer's Disease: a critique. Neurochem Int 1996, 28, 485-90.

  Haley RW, Billecke S, La Du BN. Association of Low PON1 Type Q (Type A) Arylesterase Activity with Neurologic Symptom complexes in Gulf War Veterans. Toxicology and Applied Pharmacology 1999, 157, 227-233.

  Haley RW, Fleckenstein JL, Bonte FJ, Devous MD, Marshall WW, McDonald GG, Petty F. Special Brain Scan Suggests Existence of Gulf War Syndrome. 85th Scientific Assembly and Annual Meeting Radiological Society of North America, 30 November 1999a.

  Haley RW, Horn J, Roland PS, Wilson WB, Van ness PC, Bonte FJ, Devous MD, Matthews D, Fleckenstein JL, Wians FH, Wolfe GI, Kurt TL. Evaluation of Neurologic Function in Gulf War Veterans. JAMA 1997b, 277, 223-230.

  Haley RW, Kurt TL. Self-reported Exposure to Neurotoxic Chemical Combinations in the Gulf War: A Cross-sectional Epidemiologic Study. JAMA 1997, 277, 231-237.

  Haley RW, Thomas LK, Horn J. Is there a Gulf War Syndrome: Searching for Syndromes by Factor Analysis of Symptoms. JAMA 1997a, 277, 215-222.

  HSE GM 202/93, 1993.

  Institute of Medicine. Epidemiological Study of the relationships between exposure to organophosphate pesticides and indices of chronic peripheral neuropathy, and neuropsychological abnormalities in sheep farmers and dippers. Pilkington A, Chairman. Report No TM/99/02b. Institute of Occupational Medicine, Edinburgh, 1999.

  Iowa Persian Gulf Study: Self-reported Illness and Health Status Among Gulf War Veterans. JAMA 1997, 277, 238-245.

  Jadin CL. Common Clinical and Biological Windows on CFS and Rickettsial Disease. Proceedings of 2nd World congress on Chronic Fatigue, p 35.

  Jamal GA. Adverse Drug React Toxicol Rev 1998 17, 1-17.

  Jones DA. PTSD and Gulf Veterans Illnesses. A lecture to Gulf Veterans and Families Asosciation, Doncaster, Portsmouth, and Whitley Bay, 1998, 1999.

  Kang HK, Bullman T. Mortality among US Veterans of the Persian Gulf War. New Engl J Med 1996, 335, 1498-1504.

  Kaufer D, Friedman A, Seidman S, Soeq H. Acute stress facilitates long-lasting changes in cholinergic expression. Nature 1998, 393, 373-377.

  Keen R Letter to MOD 16 October 1995.

  Klimas N, Fletcher MA. Alteration of Type 1/Type 2 Cytokine Patterns following adoptive immunotherapy of patients with CFS using autologous ex vivo expanded lymph node cells. Proceedings of 2nd World congress on Chronic Fatigue, p 80.

  Kornkven C. DOD Environmental Exposure Report: a Clarification. A Joint Project of Swords to Plowshares, National Gulf War Resource Center, and Military Toxics Project, 1998. Available at National Gulf War Resource Center, Inc. 1224 M St, Washington, DC 20005, USA. Internet: http://www.gulfweb.org/ngwrc.

  Kuby J. Immunology, 3 Edition, Freeman, New Yark, 1997.

  LAKA Foundation Depleted Uranium: A Post-War Disaster for the Environment and Health, Laka Foundation, May 1999.

  Lebleu, B, Bisbal C, Campine I, Salehz T, Demettre E, De Becker P, De Meirleir K. A 37 KDA 2-5 A Binding protein as a potential Biochemical Marker for Chronic Fatigue Syndrome. Proceedings of 2nd World congress on Chronic Fatigue, p 54.

  Lee HA. Address to Independent Panel, Mar 29 1999.

  Lee HA. Letter to Ivor Connolly, October 5 1999a.

  Lintern MC, Smith ME, Ferry CB. Effect of repeated treatment with Pyridostigmine on Acetylocholinesterase in mouse muscle. Hum Exp Toxicol, 1997, 16, 158-165.

  Lorente I, Lizcano F, Alvarez R, Diez N, Sopena M, Gil MJ, Salvador J, Cholinergic modulation of spontaneous hypothalamic-pituitary-adrenal activity and its circadian variation in man. J Clin Endocrinol Metab, 1996, 81, 2902-7.

  Mackness B, Durrington PN, Mackness MI. Polymorphisms of paraoxonase genes and low-density lipid peroxidation. Lancet 1999, 353, 468-9.

  Mackness B, Hunt R, Durrington PN, Mackness MI. Increased Immunolocalisation of Paraoxonase, Clusterin, and Apolipoprotein A-I in the Human Artery Wall with Progression of Aethersclerosis. Arteriscler Thromb Vase Biol, 1997, 17, 1233-1238.

  Mackness MI, Mackness B, Durrington PN, Fogelman AM, Berliner J, Lusis AJ, Navab M, Shih D, Fonarow GC. Paraoxonase and Coronary Heart Disease. Current Opinion in Lipidology 1998, 9, 319-3234.

  Matsumoto G. The Pentagon's Toxic Secret. Vanity Fair May 1999. Article Reveals Results Of Recent Medical Study; Nuremberg Code Violations Alleged.

  Maynard RL. Toxicology of Chemical Warfare in Clinical and Experimental Toxicology of Organophosphates and Carbamates, Ed Ballantyne B, Marrs TC. Butterworth-Heinnemann, Oxford, 1992.

  McCain WC, Lee R, Johnston MS, Whaley JE, Ferguson JW, Beall P, Leach G. Acute oral toxicity study of Pyridostigmine Bromide, Permethrin, and DEET in the laboratory rat. J Toxicol Environ Health 1997, 50, 113-124.

  McDiamid M. Unpublished data presented at National Gulf War Resource Center, Third Annual Gulf War Veterans' Illnesses Conference, Arlington, VA, 18-21 September 1998. Hooper et al Health Physics paper see text for reference.

  McIntire L. Sgt Tom Hare's Physician letter. Internet http://www.chronicillnet.org/online/McIntire.html.

  MoD Gulflink. Web-site http://www.gulflink.osd.mil/mod.uk/inex.html.

  Moriarty TJ. Gulf War Vets, Doxycycline and Miracles: the Story of Sgt Tom Hare. Internet. http://www.chronicillnet.org/online/Hare.html.

  Moss JI. Gulf War Risks. BMJ Electronic Letters, 1999, 28 January.

  Moss JI. Possible potentiation of Pyridostigmine Bromide by Pesticides. Report of the Special Investigations Unit on Gulf War Illnesses, Committee on Veterans Affairs, United States Senate. S Prt 105-39.

  Murray-Leisure K, Daniels MO, Sees J, Suguitan E, Zangwill B, Bagheri S, Brinser E, Kimber R, Kurban R, Greene WH. Mucocutaneous-Intestinal-Rheumatic Desert Syndrome (MIRDS). Definition, histopathology, incubation period, clinical course and association with desert sand exposure. Intern J Med, 1997, 1, 47-72.

  Nass M. Testimony to Committee on Government Reform, Hearing on Anthrax Vaccine Safety, 29 April 1999. See also the comprehensive documentation at http://www.anthraxvaccine.org/.

  National Gulf War Resource Center, Personal Communication, Sullivan P. 16 November 1998.

  Nicholson NL, Nicolson, GL. The Enemy—from Within. Criminal Politics 1996, pp 13-18.

  Nicolson GL, Nicolson NL. Diagnosis and Treatment of Mycoplasmal Infections in Persian Gulf War Illness—CFIDS Patients. Intl Journal of Occupational Medicine, Immunology, and Toxicology. 1996, 5, 69-78.

  Nicolson GL, Nicolson NL, Nasralia M. Mycoplasmal Infections and Fibromyalgia/Chronic Fatigue Illness (Gulf War Illness) Associated with Deployment to Operation Desert Storm. International Journal of Medicine 1997 1, 80-92.

  Nicolson GL, 1998, Written Testimony to Special Oversight Board for Department of Defence Investigations of Gulf War Chemical and Biological Incidents.

  Nicolson GL. Chronic Infections as a Common Aetiology for many Patients with Chronic Fatigue Syndrome, Fibromyalgia Syndrome and Gulf War Illnesses. Intern J Med 1997, 1, 42-46.

  O'Kane M. Did we do This: the Hidden Legacy of the Gulf War, Guardian G2 Section 21 December 1998.

  Panksepp JA. A Neurochemical Theory of Autism. Trends in Neuroscience, 1979, 2, 174-177.

  Radestsky P. Gulf War Syndrome: The Science Behind the Sickness: The Gulf War Within. Discover Magazine August 1997. Internet http://www.lawtonok.net/vva/gws.htm.

  Rea W. Environmental health Center—Dallas. Internet http://www.ehcd.com/ This site provides full details of the different programmes available.

  Reichelt KL, Hole K, Hamberger A, Saelid G, Edminson PD, Baestrup CB, Lingjaerde O, Ledaal P, Orbeck H. Biologically Active peptide—Containing Fractions in Schizophrenia and Childhood Autism. Adv Biochem Psychopharmacol. 1981, 28 627-643.

  Revell. Evidence to Defence Committee 1996.

  Richardson J, Campos Costa D. Relationship between SPECT Scans and Buspirone Tests in Patients with ME/CFS. J Chronic Fatigue Syndrome, 1998, 4 23-38.

  Riegle D. US Senate, committee on banking, Housing and Urban Affairs, Washington, 1994.

  Rockefeller JD. Is military Research Hazardous to Veterans Health. United States Senate, 1994.

  Rodriguez P. Insight Magazine 1997, volume 13, No 33 (September) and No 40 (November): Washington Times-News, Sunday 11 August 1997. Internet. http://www.gulfwarvets.com/hiv2.htm, http://www.gulfwarvets.com/hiv.htm.

  Rook G and Zumla A. Gulf War Syndrome: is it due to a systemic shift in cytokine balance towards a Th2 Profile? Lancet 1997, 349, 1831-33.

  Rosenstock L, Keifer M, Daniell WE, McConnell R, Claypole K. Chronic central nervous system effects of acute organophosphate pesticide intoxication. Lancet 1991, 338, 223-227.

  Rostker B. Environmental Exposure Report: Depleted Uranium in the Gulf, 1998. Department of Defense, Office of the Special Assistant Gulf War Illnesses, Washington DC, USA.

  Roth JA. Mechanistic Bases for Adverse Vaccine Reactions and Vaccine Failures. Advances in Vet Med 1999, 41, 681-700.

  Sharabi Y, Danon YL, Berkenstadt H, Almog S, Mimouni-Bloch A, Zisman A, Dani S, Atsom, J. Survey of Symptoms following the intake of Pyridostigmine Bromide during the Persion Gulf War. Isr J Med Sci 1991, 27, 656-8.

  Sharma H. Unpublished data.

  Shattock P and Savery D. Autism as a Metabolic Disorder, 1997, Autism Research Unit, Sunderland.

  Shattock P, Kennedy A, Rowell FJ, Berney. TP. Role of Neuropeptides in Autism and their Relationship with Classical Neurotransmitters. Brain Dysfunction 1991, 4, 301-307.

  Shattock PEG, Mill MJ, Savery. D. Rapid Analysis of Low Levels of Indolylacroylglycine in Human Urine by HPLC. J Chromatography, B, 1998, 712, 51-58.

  Shattock PEG, Savery D. Evaluation of Urinary profiles obtained from People with Autism and Associated Disorders. Part 2: The Role of Vaccines in the Causation of Autism and Related Disorders. Living and Learning with Autism, St Aidan's College, Durham, Conference Proceedings, 1997. pp 209-220. Available from Autism Research Unit, University of Sunderland, Sunderland SR2 7EE, UK.

  Showalter E. It's All in the Mind: We are living in an age of hysteria says American Academic, John Carlin, Independent on Sunday, 27 April 1997.

  Specter A. Report of the Special Investigation Unit on Gulf War Illnesses, Committee on Veterans' Affairs, United States Senate, 105th Congress, 1998.

  Stead CG. Oil Fires Petroleum and Gulf War Illness. Presentation to CDC Conference on the Health Impact of Chemical Exposures during the Gulf War. Submissions were also made to Burton and Shays Committees.

  Studham C. Information supplied by OP Information Network, Elizabeth Sigmund, to House of Commons Defence Committee, 1994-1996. Testimony of a Paramedic on use of Malathion.

  Suhadolnik RJ, Horvasth SE, et al. Diagnosis of Chronic Fatigue Syndrome: Determination of a low Molecular Weight 37 KDA 2-5 a Dependent Rhase L in Peripheral Blood mononuclear Cell Extracts. Proceedings of 2nd World Congress on Chronic Fatigue, p55.

  Thomas W. Bringing the War Home, Earthpulse Press, Anchorage, 1998.

  Unwin C, Blatchley N, Coker W, Ferry S, Hotopf M, Hull L, Ismail K, Palmer I, David A, Wessley S. Health of UK servicemen who served in the Persian Gulf War. Lancet, 1999, 353, 169-178.

  Urnovitz HB. Unpublished data presented at National Gulf War Resource Center, 3rd Annual Gulf War Veterans' Illnesses Conference, Arlington, VA, 18-21 September 1998.

  Urnovitz HB, Murphy WH. Clinical Microbiology Rev 1992, 9, 72-99.

  Vicker MG. Radiosensitivity Mechanisms at Low Doses: Inflammatory Responses to micro-Gray Radiation levels in Human Blood, International Perspectives in Public Health, 1993, 9, 4-20.

  Van Kleist JR. Gulf War Veterans and the Military Medical Establishment, 3 September 1998, posted at http://www.gulfwarvets.com/ijon.htm.

  Wakefield AJ, Murch SH, Anthony A, Linnell J, Casson DC, Malik M, Berelowitz M, Dhillon AP, Thompson MA, Harvey P, Valentine A, Davies SE, Walker-Smith JA. Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children. Lancet, 1998, 351, 637-64.

  Waring RH, and Ngong JM, in Biological Perspectives in Autism, Conference Proceedings from Autism Research Unit, University of Sunderland, UK 1993 pp 25-33. And unpublished data.

  Watkins A (Ed) Mind-Body Medicine. A Clinicians guide to Psychoneuroimmunology, Churchill Livingstone, 1997.

  Wessley S, Nimnuah C, Sharpe M. Functional Somatic Syndrome: One or Many. Lancet 1999, 354, 936-9.

  Whiteley P, Rodgers J, Savery D, Shattock PEG. A gluten-free diet as an intervention for autism and associated spectrum disorders: Preliminary Findings. Autism Int J Res Pract 1999, In Press.

  Wickelgr I. The big easy serve up a feast for to visiting neuroscientists; rat model for Gulf War Syndrome? Science 1998, 278, 1404.

  Worthington-Russell Information supplied by OP Information Network, Elizabeth Sigmund, to House of Commons Defence Committee, 1994-96. Testimony of Sgt Worthington AJ, Environmental Health Technician on use of Pesticides. Commendation by Lt Colonel BK Reece-Russell.

  Zajic VS. Available at http://www.members.tripod.com/vzajic/vzajic.html. This is a new site which provides much detail and many references about the scientific aspects of radiation and DU. I am indebted to Dr Zajic for most of the pictures and the cartoon used in this lecture.

December 1999


 
previous page contents next page

House of Commons home page Parliament home page House of Lords home page search page enquiries

© Parliamentary copyright 2000
Prepared 28 February 2000