Select Committee on Science and Technology Sixth Report


DELIVERY OF TREATMENT

43. During each one of our visits to cancer research centres, both in the UK and overseas, practitioners impressed upon us that good clinical environments and structures were essential to allow clinical research into new diagnostic and therapeutic techniques to be developed and assessed.[58] Only if there is such provision, and an effective interface between laboratory and clinic, can the UK develop new approaches to cancer treatment. Especially in the light of the expansion in basic understanding of cellular processes and malignancy that will emerge from the human genome project, it is of paramount importance that there are effective mechanisms for clinical trials and delivery of new clinical interventions. Provision of these research resources is key to improving cancer treatment and the outcome for cancer patients.

Cancer Treatment Networks (Calman-Hine Networks)

44. As we noted above, cancer patients are usually referred by GPs to a district general hospital for diagnosis and treatment. For rarer cancers or highly specialised treatments, patients may be further referred to a specialist centre. The quality of cancer care delivered is dependent on the expertise of the healthcare professionals in each of these environments and on the relationship between them. The importance of good quality cancer networks in terms of delivering high quality cancer care was recognised in the Calman-Hine report (see para 1). The cancer treatment networks proposed in the Calman-Hine report are intended to operate on a "hub and spoke" model, where the hub is the cancer centre and the spokes reach out to the local cancer units in district general hospitals and into primary care. These networks are proposed as the ideal model for delivering a uniformly high standard of cancer treatment, as close to the patient's home as possible. We believe that cancer care networks should also provide an essential resource for clinical research and that research based on cancer networks should be given more emphasis than was evident in the Calman-Hine report itself. Clinical research should be an explicit part of the remit of both cancer centres and their associated units.

CANCER CENTRES

45. Cancer centres are intended to serve populations of one to two million and should be able to offer the full range of specialist cancer services including treatments for rarer cancers.[59] Such a population base is necessary if the specialists are to see sufficient numbers of patients to ensure that the relevant expertise is built up and maintained. Normally part of a large general hospital, cancer centres are intended to provide support for paediatric and adolescent cancers; assessment and management of rare cancers; specialist surgical services including reconstructive surgery; intensive chemotherapy and radiotherapy; and specialist expertise in palliative care.

LOCAL CANCER UNITS

46. Local cancer units, based in district general hospitals, should be the main delivery route for most routine general cancer treatment. The Calman-Hine report sees the service in cancer units as being "in many ways surgically led", suggesting that in future the management of cancer should be carried out by consultant surgeons who specialise in treatment of both cancer and non-malignant conditions in a particular anatomical area.[60] Cancer units should offer "site-specific" clinics with a consultant and with surgical sub-specialisation in the common cancer sites. Cancer units must therefore serve a population large enough to provide a sufficient volume of work for each common cancer to support sub-specialisation. Patients with rarer cancers or those requiring expensive, specialist equipment or expertise would be referred to the cancer centre. We noted on our visit to the Christie Hospital Cancer Centre in Manchester that cancer specialists from the centre travelled out to clinics in the district cancer units to provide clinics with specialist expertise not available locally on a full-time basis. This is not the only model that can be used to implement the Calman-Hine recommendations. Alternative arrangements are known to exist.

47. The pivotal rôle of specialist nurses in the delivery of both care and clinical trials to cancer patients was made apparent during our visits to cancer centres in the UK.[61] Most major cancer centres employ an increasing number of highly skilled research nurses who deliver clinical trials to GCP standards. It would be impossible to carry out any significant amount of clinical research without them. Nursing care for in-patients and out-patients must be planned and led by nurses with post-registration education and training in oncology. There should also be ready access to specialist nurses with experience in the different facets of caring for the cancer patient including the management of pain and other symptoms, counselling and psycho-social support. Access to palliative medicine, psychological support and other forms of supportive care should be available in each cancer unit.

PRIMARY CARE

48. The Calman-Hine report calls for a close relationship between the primary care sector and secondary care services provided by the cancer units and centres. This relationship should be one of partnership in continuing care rather than the temporary or permanent transfer of responsibility for the patient to the hospital specialist.

IMPLEMENTATION OF THE CALMAN-HINE RECOMMENDATIONS

49. In October 1999 the Government appointed a National Cancer Director, Professor Mike Richards, "to spearhead the improvements necessary to cancer services", including "building on the principles set out in the Calman Hine report".[62] Professor Richards told us that one of his top priorities was to develop the workforce necessary for the specialist teams needed to deliver high-quality cancer care in line with the Calman-Hine report.[63] He also told us that there would be 34 cancer networks.[64] Surprisingly neither he nor the Minister was willing to say precisely how many of these networks or cancer centres had been established so far. The Minister told us that "in some areas they are very well embedded and working very well. In other areas clearly there is more progress to make".[65] Professor Ponder of Cambridge University estimated that 15 or 20 centres in England and Wales would claim to have full cancer centre status but he was "not sure how well some of them fulfil it".[66]

50. Professor Richards is developing a National Cancer Plan which is to be published shortly. The plan will focus on certain goals:

  • to save lives through prevention, earlier detection and improved treatment of cancer and to improve outcomes in the future through research and development (R&D);

  • to improve the quality of life of those affected by cancer through reducing delays and through improvements to the provision of supportive care; and

  • to reduce inequalities in incidence, mortality, survival and quality of care through effective delivery of services to all groups in society.[67]

51. Developing the highest possible standards of cancer care across the whole NHS is a major challenge. The evidence we have seen reveals shortages in both medical and clinical oncologists, specialist cancer nurses, data managers, physicists, technologists, histopathologists, cytologists, radiologists and radiographers and in equipment for diagnosis and radiotherapy.[68] Effecting change in an organisation the size of the NHS is a complicated task. The changes needed in service levels and organisational structure will require not only a large increase in investment in staffing, equipment and training, but also a shift in clinical culture. This investment is essential if the vision set out in the Calman-Hine report is to be realised. In Northern Ireland, where the Calman-Hine model is being followed closely, and with a good deal of success, substantial capital investment, as well as inspired leadership, has been required.[69]

52. We acknowledge that neither the transformation of existing cancer services into the structure set out by the Calman-Hine report, nor the delivery of the highest possible standards of cancer care across the NHS with a significant research remit, can be delivered overnight. It is however, an objective worthy of pursuit and a critical test for Government. The Government will have to deliver both the considerable financial resources and the managerial and political leadership necessary to effect this change, if it is to meet its own target of reducing deaths from cancer by 20 per cent in those aged less than 75 years by 2010. We note that the forthcoming National Cancer Plan will have important goals in terms of patient outcomes but these will only be deliverable in the context of major organisational and funding changes. If we do not get our structures and strategies right, cancer patients will miss out on opportunities to benefit from leading-edge treatments and the opportunity of significantly enhanced survival prospects. We recommend that the National Cancer Plan, which must incorporate the development of a research ethos in cancer centres, include built-in milestones and explicit estimates for the additional capital and recurrent financial resources necessary to deliver the required elements of:

  • organisational change;

  • additional specialist and support staff;

  • equipment, and

  • new treatments and therapeutic techniques.

National Cancer Standards Framework

53. Providing the right organisational structure for research into cancers and delivering cancer care is essential for improving outcomes for cancer patients. It is, however, also necessary to ensure that the treatment provided in the new organisation is the most appropriate. Identifying best clinical practice for patient outcomes and communicating this across the cancer networks will help to ensure a uniformly high standard of care. The Department of Health told us that "Guidance on improving outcomes for breast, colorectal, lung and gynaecological cancers has been published and targeted funding has been allocated to improve service delivery and in particular to establish specialist teams".[70] There are also plans to publish guidance covering upper gastrointestinal, urological, head and neck cancers and haematological malignancies.[71] Professor Crowther, President of the Association of Cancer Physicians and Emeritus Professor of Medical Oncology at Manchester University, told us that "Good clinical scientific research can only follow from the application of 'Good Clinical Practice Guidelines'... These are not implemented widely because of under-funding for staff".[72] He estimated that "no more than 50 per cent" of patients were treated in accordance with those guidelines.[73]

54. The Government has recently launched a consultation on a manual for national cancer care standards and performance indicators for cancer care, initially for breast, bowel and lung cancer.[74] These are intended to ensure high standards of practice, to encourage good communications with patients, and to monitor cancer incidence, waiting times for treatment and patient satisfaction.

55. Guidance and monitoring will not alone deliver high standards in care or research. Leadership and funding, supported by sound research-based evidence are required to ensure that high standards are implemented across the NHS. For example, guidance on gynaecological cancers, published in July 1999, recommended that for ovarian cancer "paclitaxel [Taxol] plus carboplatin should be standard therapy unless there are particular concerns about toxicity in relation to the individual patient's fitness".[75] It was not, however, until May 2000 that NICE issued guidance to the effect that "paclitaxel in combination with a platinum therapy (cisplatin or carboplatin) should be the standard initial therapy for patients with ovarian cancer following surgery".[76] Thus many oncologists were faced with national guidance to use a particular drug which, in the absence of NICE approval, the Health Authority was unwilling to fund. There is no guarantee that NICE-approved treatments will be funded by Health Authorities and, similarly, there seems to be no guarantee that clinicians will automatically follow the guidance provided. Cancer patients are often very well informed about the latest treatments and will no doubt become informed of the national guidance on treatment standards. We welcome the introduction of national guidance on improving outcomes for cancer patients and the initiatives to monitor delivery. It is, however, wholly unacceptable that delays in implementing the guidance on treatment should be the result of tardiness on the part of NICE or contrary funding decisions on the part of Health Authorities.

Education and Prevention

56. Another of the main elements of the Government's strategy to tackle cancer is through prevention and public health education. There are several well-recognised risk factors associated with cancer which result from lifestyle, the most significant and best-known being tobacco smoking. The Government estimates that "about a third of cancer deaths are caused by smoking".[77] The links between cancer incidence and diet, alcohol consumption, and exposure to sunlight, certain infections or certain chemicals (either in the workplace or through environmental pollution) have been clearly demonstrated. These are all areas where Government can take action either through public health campaigns or through legislation to reduce or prevent exposure. Such legislative actions, which require research to establish the validity of the link between exposure and disease, include pollution controls and health and safety at work regulations. These are enforced by Government agencies such as the Environment Agency and the Health and Safety Executive (HSE). The HSE has an extensive research programme to identify occupational carcinogenic agents and to prevent exposure of workers.[78]

57. Public health awareness campaigns are important and can be successful. Most people, including children, are aware that smoking causes cancer of the lung and other organs. The Government's recent measures to intensify action to reduce smoking include restricting tobacco advertising and the promotion of nicotine replacement therapy.[79] Nevertheless Professor Selby of the ICRF told us that "there will have to be a significant reduction in smoking quite quickly" if the Government is to meet its target for reducing cancer deaths over the next 10 years, although it is questionable whether even a large, immediate decline in smoking would produce a significant decline in lung cancer deaths in this time frame.[80] We welcome the Health Committee's recent Report on The Tobacco Industry and the Health Risks of Smoking.[81]

58. The GP also has an important rôle in cancer prevention. The GP is in a prime position to advise patients of lifestyle factors which can affect cancer such as diet, smoking, alcohol consumption and exposure to sunlight. Advice from GPs can be tailored to the individual which will often be more effective than mass public health programmes which by necessity can only disseminate messages broadly. GPs are also in a good position to promote the use of self-examination to help with early detection, particularly for skin, breast and testicular cancers. The rôle of the GP is particularly important in deprived areas where low levels of literacy, poor education and cultural barriers to seeking diagnosis and treatment may all contribute to late diagnosis and poorer cancer outcomes.[82] In such areas the national public health messages may not get across to individuals as easily as in more affluent areas.


58  See Annexes 1-8. Back

59  Q. 3. Back

60  Calman-Hine report, page 9. Back

61  See, for example, Annex 7. Back

62  Ev. p. 1. Back

63  Q. 2. Back

64  Q. 499. Back

65  Q. 499. Back

66  Q. 469. Back

67  Department of Health, press notice 2000/0356, 15 June 2000. Back

68  Oncologists are doctors who treat cancer patients. Medical oncologists treat cancer with chemotherapy and clinical oncologists treat cancer with radiotherapy although there is some overlap between these disciplines. Back

69  See Annex 4. Back

70  Ev. p. 2. Back

71  Ev. p. 2. Back

72  Ev. p. 133. Back

73  Q. 369. Back

74  Department of Health, press notice 2000/0356, 15th June 2000. Back

75  Improving outcomes in gynaecological cancers - The manual, NHS Executive, July 1999, p.31. Back

76  Guidance on the Use of Taxanes for Ovarian Cancer, NICE, May 2000. Back

77  Saving Lives: Our Healthier Nation, p. 63. A similar estimate has been made by the National Cancer Policy Board in the United States. Back

78  See: Ev. pp. 313-321. Back

79  Saving Lives: Our Healthier Nation, p. 64. Back

80  Q. 294. Back

81  Second Report from the Health Committee, Session 1999-2000, on The Tobacco Industry and the Health Risks of Smoking, HC 27-I. Back

82  See Q. 579; Saving Lives: Our Healthier Nation, p. 62. Back


 
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