Select Committee on Health Minutes of Evidence


Memorandum by HIV/STI Division PHLS Communicable Disease Surveillance Centre (SH63)

SEXUAL HEALTH IN BRITAIN: THE CHANGING EPIDEMIOLOGY OF HIGH-RISK SEXUAL BEHAVIOURS, AND STIs INCLUDING HIV

1.  SUMMARY OF KEY POINTS

  1.  The past decade has seen substantial increases in high-risk sexual behaviours in the British population. Although condom use has increased, it is likely the increase in unsafe sex has been even greater.

  2.  Although substantial declines in STI incidence were observed throughout the 1980s and early 90s, new diagnoses of STIs have risen continually since 1995. Diagnoses of chlamydia, gonorrhoea and syphilis have all more than doubled over the past five years.

  3.  Distinct "core-groups" (eg young people, gay and bisexual men, some ethnic minorities) bear a disproportionate burden of disease.

  4.  New treatments have had a major impact with rises in HIV prevalence (due to decreasing numbers of deaths at a time when new diagnoses are increasing). As a result, the number of people requiring long term treatment is increasing rapidly.

  5.  Gay men remain the group at highest risk of acquiring HIV in the UK, and there is evidence that transmission through sex between men is continuing at a substantial rate.

  6.  Over 70 per cent of heterosexually acquired HIV infections diagnosed in the UK in 2000-01 were in people from, or associated with exposure in, Africa.

  7.  Although the potential still exists for HIV transmission through injecting drug use there is no evidence of significant current spread amongst IDUs in the UK.

  8.  London, Edinburgh, Brighton and Manchester are the cities in the UK with the largest HIV infected populations, although other metropolitan areas have significant numbers of HIV infected residents.

  9.  Although preventable HIV infections are still occurring in children, the proportion of maternal HIV infections detected in pregnancy has increased especially in London.

  10.  Poor GUM clinic access is now widespread throughout England. The median time to first appointment in 2002 has lengthened to 12 days for men and 14 days for women.

2.  INTRODUCTION: THE PHLS COMMUNICABLE DISEASE SURVEILLANCE CENTRE

  2.1  The Public Health Laboratory Service is a network organisation consisting of nine Group Laboratories based on 49 sites strategically located throughout England and Wales, which are linked to specialist microbiological reference units and epidemiological experts. The Communicable Disease Surveillance Centre, CDSC, was set up by the PHLS on 1 January 1977 to provide a highly active centre for the surveillance and control of infectious disease in support of public health physicians and others involved in the investigation and control of communicable disease. It now forms a unified central epidemiological unit of the PHLS and is the national centre for the surveillance and control of communicable disease in England and Wales.

  2.2  The main objectives of the HIV/STI Division of the CDSC are to determine and describe the geographic, demographic and risk factor distributions of STIs and BBVs; to monitor the progression of STIs and BBVs in "at risk" populations and to estimate incidence of particular infections (especially HIV) in important behavioural risk groups; to provide data and analyses for planning and targeting preventative activities (health promotion) aimed at reducing risk behaviours and interrupting transmission of STIs and BBVs; and to establish and maintain appropriate surveillance mechanisms to facilitate the early detection of significant changes in the epidemiology of STIs and BBVs.

  2.3  This report presents the most up-to-date information on the status of the HIV and STI epidemics in England and Wales, as well as the behaviours that transmit them. The evidence is based upon data derived from existing HIV/STI surveillance programmes as well as recently published research studies. Further information on the structure of the HIV/STI Division, or about the nature, range and outputs of our surveillance programmes may be obtained from the PHLS website located at www.phls.co.uk.

3.  RECENT CHANGES IN POPULATION SEXUAL BEHAVIOUR: A MAIN DRIVING FACTOR FOR RISING HIV AND SEXUALLY TRANSMITTED INFECTIONS (STIS).

  3.1  Population patterns of sexual behaviour are major determinants of sexually transmitted infections (STI) and HIV transmission. The most recent data on sexual behaviour in Britain are derived from the MRC funded second National Survey of Sexual Attitudes and Lifestyles (Natsal 2000). This study confirmed that there have been many changes in both social norms, reflected in more tolerance towards sexual diversity, and in sexual behaviour in the UK in the past decade. 1 There has been an increase in a wide range of behaviours associated with HIV and STI transmission, including numbers of heterosexual partners, age at first sexual intercourse, homosexual partnership, concurrent partnership, heterosexual anal sex, and payment for sex. 1

Key point one

The past decade has seen substantial increases in high-risk sexual behaviours in the British population. Although condom use has also increased, this is likely to have been offset by greater increases in unsafe sex.

  3.2  For both men and women the numbers of lifetime heterosexual partners have increased substantially since 1990 (Figure 1), and these increases have been highest in young people. 1,2 The mean number of lifetime partners has increased from 8.6 and 3.7 partners ever for men and women respectively in 1990 to 12.7 and 6.5 in 2000. 1

  3.3  Concurrent partnerships (having more than one sexual partner at the same time) are important for STI transmission dynamics, as they increase the probability that an infection will be passed on to more than one person. The proportion of men and women who had concurrent relationships in the past year has also increased since 1990 and was 14.6 per cent and 9.0 per cent respectively in 2000 (Figure 2). The rate was highest in young people, with over 20 per cent of 15-24 year old men and 15 per cent of 15-24 year old women having a concurrent partnership in the last year. 1

  3.4  While condom use has increased in the UK, the increase in numbers of sexual partners may have served to discount some of the public health advantages of this increase. Overall the proportion of the population, who reported two or more partners in the past year and did not use condoms consistently, had increased since 1990, from 13.6 to 15.4 of men and from 7.1 per cent to 10.1 per cent of women (Figure 3).

  3.5  Age at first intercourse has declined from 21 for women and 17 for men surveyed in 1990 to 16 for men and women born in the early to mid 1980s. 2 Young people do not always have the negotiation skills to ensure the use of condoms consistently and effectively, and yet are a group with both higher rates of partner change, and more concurrent partners. 1, 2

  3.6  The proportion of men in Britain who had ever had a homosexual partner increased from 3.6 per cent in 1990 to 5.4 per cent in 2000, and the proportion that had had a homosexual partner in the last five years also increased (Figure 2). 1 Community surveys of men who have sex with men have seen high risk sex increase since 1996. 3,4,5

  3.7  Unsafe sex amongst men who have sex with men, particularly occurring with a partner of unknown HIV status, has increased in London since 1996. 1,4 The proportion of gay men in London reporting unprotected anal intercourse (UAI) in the past year increased from 32 per cent in 1996 to 44 per cent in 2000 (Figure 4). Evidence suggests that these increases in UAI are with both regular and casual partners. 4 Recent growth in traditional (such as saunas and cruising grounds) and new (websites and internet chat rooms) sexual market places has increased the opportunity for men who have sex with men to acquire new sexual partners. 6

  3.8  Implications for GUM services: The observed increases in high-risk sexual behaviour have driven, and continue to drive, global increases in HIV and STI transmission. In turn, these place additional pressures on existing services.

4.  RECENT EPIDEMIOLOGY OF SEXUALLY TRANSMITTED INFECTIONS

  4.1  One of the most sensitive markers of changes in high-risk sexual behaviour is the resultant increase in transmission and diagnosis of sexually transmitted infections. Sexually transmitted infections (STIs) cause considerable reproductive morbidity and poor health outcomes including pelvic inflammatory disease (PID), infertility, ectopic pregnancy, cervical cancer, neonatal disorders and death. 7 Early diagnosis and treatment of STIs, as well as targeted prevention efforts, can significantly reduce the likelihood of these complications occurring.

  4.2  The long established network of over 200 GUM clinics in England and Wales, and the robust STI surveillance (KC60) programme are well placed to identify these increases early. Unsurprisingly, the past decade has seen substantial changes in the epidemiology of STIs and HIV infection.

Key point two

Although substantial declines in STI incidence were observed throughout the 1980s and early 90s, new diagnoses of STIs have risen continually since 1995. Diagnoses of chlamydia, gonorrhoea and syphilis have all more than doubled over the past five years.

  4.3  Diagnoses of acute bacterial STIs in genitourinary medicine (GUM) clinics in England, Wales and Northern Ireland more than doubled between 1995 and 20008 and specifically: gonorrhoea increased by 102 per cent (10,204 to 20,663 cases) (Figure 5); chlamydia increased by 107 per cent (30,877 to 64,000 cases) (Figure 6), and infectious syphilis increased by 145 per cent (136 to 333).

  4.4  Preliminary analyses of the latest data suggests there were further significant increases in 2001. 9 These rises are mostly associated with an increase in higher risk sexual behaviour although greater testing for chlamydia has also contributed. 10 Diagnoses of STIs had fallen sharply in the mid to late 1980s in the wake of the HIV and AIDS epidemic and had remained at low levels until the mid-1990s. 11

  4.5  However, chlamydial and gonococcal infections in females usually show no symptoms which means they often do not get diagnosed. The chlamydia screening pilot in Portsmouth and Wirral, which was funded by the Department of Health and co-ordinated centrally by the Public Health Laboratory Service Communicable Disease Surveillance Centre, tested all sexually active young women attending a range of health care settings, including general practice and family planning clinics, regardless of whether they had symptoms. Approximately 17,000 women were tested between September 1999 and August 2000, equivalent to about 45 per cent of the sexually active female population aged under 25 years in those areas. 12 The results suggested that between 10 per cent and 11 per cent of women aged under 25 and attending health care services may be infected with chlamydia. 13 Many of these women would have been unaware of their infection and therefore at risk of developing chlamydial complications.

  4.6  Implications for GUM services: Increasing STI diagnoses reflect increasing GUM clinic throughput as well as rising disease prevalence in the community. As many clinics are now operating at maximum capacity, the effectiveness of GUM clinic based prevention interventions such as partner notification and behavioural counselling are at risk as clinics fail to cope with demand.

Key point three

Distinct "core-groups" (eg young people, gay and bisexual men, some ethnic minorities) bear a disproportionate burden of disease.

  4.7  Certain groups in the population tend to be at particular risk of infection and re-infection with STIs. These include:

  4.8  Young people, particularly teenage females. The highest rates of gonorrhoea and chlamydia occur among teenage females. 14 Over 40 per cent of the 6,313 females diagnosed with gonorrhoea in 2000 were under 20 years old, and among 12 to 15 year old females diagnosed with gonorrhoea, almost a quarter will return with another episode of gonorrhoea within a year. 15,16

  4.9  Gay men. There have been numerous large outbreaks of syphilis in England over the last few years, notably in Manchester, Brighton and most recently in London, where over 290 cases were diagnosed in the last year. 17,18 These outbreaks have predominantly involved gay men, many of whom were also infected with HIV. 19

  4.10  Black ethnic minorities. Several studies have shown particularly high rates of bacterial STIs, especially gonorrhoea, among the black Caribbean population. 20, 21, 22, 23 In London, gonorrhoea rates are thought to be 10 times higher in black ethnic groups than in whites. 24 A quarter of black Caribbeans diagnosed with an acute STI will be diagnosed with another acute STI within a year. 25

  4.11  Although sexual behaviour is a key determinant of STI transmission, other factors may be associated with an increased probability of disease spread. These include: high levels of asymptomatic infection; ineffective partner notification measures; poor access to GUM clinic services. 26, 27, 28, 29, 30 Consequently, the development of prevention measures should always consider not only the behavioural context, but the provision and utilisation of sexual health services as well.

  4.12  Implications for GUM services: Inequalities in GUM service provision are exacerbated in poor urban areas where high disease prevalence, increasing demand, poor access times and overstretched staff result in a negative feedback loop of service deterioration. The inverse-care law, whereby those in greatest need often have the poorest access to GUM services, applies equally well to Britain today.

5.  RECENT EPIDEMIOLOGY OF HIV INFECTION

  5.1  Population changes in sexual behaviour will also influence the transmission of HIV infection, however other factors eg HIV testing behaviours, patterns of health service utilisation, in-migration from high-prevalence areas, patterns of injecting drug use, and vertical (mother to child) transmission also influence the distribution of this disease in the population.

  5.2  Nevertheless, HIV continues to be the most important communicable disease in the UK. It is an infection associated with serious morbidity, high costs of treatment and care, significant mortality and, since it affects mainly younger adults, high number of potential years of life lost. Because HIV is a chronic disease, diagnosis of HIV does not necessarily represent recent infection.

  5.3  It is estimated there are about 33,500 HIV infected people alive in the UK of whom about 9,400 have not yet had their infection diagnosed. The HIV epidemic in the UK is broadly similar to that of much of Northern Europe (Germany, Holland and the Scandinavian countries), while South West Europe (Spain, Portugal, Italy, France) has experienced a much larger epidemic, especially among IDUs. A rapidly spreading mainly IDU epidemic is currently occurring in the Baltic States, the Russian Federation and other Eastern European countries but this has not so far impacted on the UK. The sub-Saharan epidemic however has had a large impact as the detailed notes below illustrate.

Key point four

The impact of new treatments on AIDS incidence and deaths—New treatments have had a major impact with rises in HIV prevalence (due to decrease in death rates) and increases in the number of people requiring long term treatment.

  5.4  Beginning in 1995, highly active antiretroviral therapies began to have a major impact on AIDS incidence and deaths from AIDS in the UK. Figure 7 shows the reduction for the period 1996-01. There were dramatic falls in 1996-98 and the lower numbers of AIDS cases and deaths have been sustained since then. That this is an effect of treatment is evidenced by the fact that the reduction is only seen in those who have their infection previously diagnosed. A large proportion of the AIDS cases now are in those who don't have their HIV diagnosed until they develop an AIDS defining illness.

  5.5  The decrease in deaths and increasing new diagnoses has resulted in rising numbers of diagnosed HIV infected people. The increase was from 14,206 in 1996 to 23,017 in 2000, and if the trend continues will result in almost 34,000 diagnosed HIV infected people alive in 2005.

  5.6  Despite the enormous promise of treatment advances, the problems of side effects, compliance and the development of resistant strains of HIV, all temper optimism at this stage.

  5.7  Implications for GUM services: As people live longer with HIV, the increasing prevalence have placed substantial pressures on existing services to fund expensive anti-retroviral therapy, often at the expense of other HIV/STI prevention interventions.

Key point five

Gay men remain the group at highest risk of acquiring HIV in the UK and there is evidence that transmission through sex between men is continuing at a substantial rate.

  5.8  In the 10 years from January 1992 there were almost 14,000 new diagnoses of HIV infection acquired through sex between men (Figure 8). Although some of these will have been acquired earlier in the course of the UK epidemic, there is substantial evidence pointing to continuing transmission in the 1990s. This includes:

    —  infections being diagnosed in those who have previously tested negative in recent years (seroconvertors)

    —  infections newly diagnosed in under 25s many of whom will have only recently become sexually active

    —  no ageing cohort effect (median age and median CD4 all count have remained fairly constant in those newly diagnosed in the last 10 years)

    —  acute STIs are occurring in both diagnosed and undiagnosed HIV positive men (Fig.5)

    —  behavioural surveys suggest that risk taking is increasing

    —  innovative new tests ("detuned assay") showing an HIV incidence of around 3 per cent (MSM attending clinics having syphilis tests)

  5.9  88 per cent of HIV reports in men who have sex with men (MSM) in the last five years for whom we have reported ethnicity are white. New diagnoses are occurring across the age spectrum, not only in younger gay men. The annual prevalence survey shows that men who have sex with men constitute the largest number of HIV infected people within the UK (table 1).

Key point six

Over 70 per cent of heterosexually acquired HIV infections diagnosed in the UK in 2000-01 were in people from, or associated with exposure in, Africa.

  5.10  The rapid rise in new diagnoses in those who have acquired HIV heterosexually is shown in (Figure 8). 71 per cent of the new diagnoses ascribed to heterosexual transmission in 2000 and 2001 were in people from or who acquired their infection in Africa (2895 of 4106). Although in the early 1990s this was mainly in people from Uganda, in more recent years increases have been seen in new diagnoses from other African countries, especially Zimbabwe.

  5.11  The numbers of those newly diagnosed each year whose only exposure is heterosexual sex within the UK is small—comprising less than 15 per cent of the total heterosexual reports. However, those newly diagnosed who have a heterosexual partner who is an IDU or bisexual man are decreasing in numbers—only 3.5 per cent of the new diagnoses in 1997-01 were in this category. In contrast numbers acquiring HIV heterosexually from a partner who acquired their infection heterosexually are increasing slowly and formed 9.5 per cent of the new diagnoses of heterosexually acquired infection diagnoses in the five years 1997-01.

  5.12  Implications for GUM services: The changing epidemiology means that GUM services must increasingly adapt to the new clientele with the provision of culturally competent services.

Key point seven

Although the potential still exists for HIV transmission through injecting drug use there is no evidence of significant current spread amongst IDUs in the UK.

  5.13  Drug injecting has played a leading role in the spread of HIV infection in South Western Europe and in parts of Eastern Europe and the possibility still exists in the UK both for explosive outbreaks (as experienced in the mid 1980s in Edinburgh) and ongoing transmission in injecting drug users. In the UK, data from the Unlinked Anonymous (UA) programme suggest a prevalence of about 1 per cent among injecting drug users (IDUs) in contact with drug agencies.

  5.14  Over recent years the percentage of IDUs sharing needles or syringes has risen dramatically. In 2000, almost a third (31 per cent) of current injectors reported sharing within the previous month, the figure was higher in women (39 per cent) and in London (41 per cent). In addition laboratory reports of acute Hepatitis B in IDUs are rising as well as the prevalence among recent injectors (7 per cent, in 2000).

  5.15  Injecting drug use is also the main transmission route for the hepatitis C virus (HCV). UA data has demonstrated an overall prevalence of 33 per cent of HCV among current injectors and a linear relationship with injecting duration which is indicative of ongoing transmission (Figure 10).

  5.16  There is little doubt that, were it not for needle exchange programmes, we would have seen much larger numbers of HIV infected IDUs with the potential for transmission to their sexual partners. The experience of other countries shows that it is imperative that these programmes are sustained, and surveillance maintained to a high level in order to detect any increase in HIV infection in IDUs in the UK.

Key point eight

London, Edinburgh, Brighton and Manchester are the cities in the UK with the largest HIV infected populations, although other metropolitan areas have significant numbers of HIV infected residents.

  5.17  There is a very great variation in geographical distribution of HIV infected people. 63 per cent of the cumulative total of diagnosed HIV infected people are resident in London (Fig. 11). Furthermore the Unlinked Anonymous testing programme shows that among STD clinic attenders, HIV positivity rates are about five times higher in gay men, and eight times higher in heterosexual men and women in London than they are in the rest of England and Wales.

  5.18  Among the UK IDU population it is estimated that around 50 per cent (30 to 70,000) are resident in London. Further, data from the UA programme indicates a much higher prevalence of HIV (3.6 per cent compared to 0.21 per cent), Hepatitis B (26 per cent compared to 20 per cent) and Hepatitis C (48 per cent compared to 30 per cent) in London resident IDUs compared to the rest of England and Wales.

Key point nine

Although preventable HIV infections are still occurring in children born in the UK, the proportion of maternal HIV infections detected in pregnancy has increased especially in London.

  5.19  HIV infection among pregnant women has assumed greater public health importance since it became known that the use of treatment by the mother, caesarean section and the avoidance of breast-feeding reduces the risk of mother to child transmission of HIV to from one in four to less than one in 50.

  5.20  The prevalence of HIV infection among pregnant women is greatest in inner London. Of women delivering during the first half of 2001, almost 0.5 per cent of pregnant women delivering in inner London, 0.3 per cent of women in outer London and 0.04 per cent outside London were infected with HIV. Prevalence has increased steadily in all areas of England, with the greatest increase occurring outside inner London (Figure 12).

  5.21  There has been a steady increase in the proportion of HIV-infected women diagnosed before delivery, allowing the women to access treatment to prevent transmission to the baby. During 2000, an estimated 87 per cent of HIV-infected pregnant women in inner London were diagnosed before they gave birth, thereby exceeding the national target of 80 per cent set by the Department of Health for 2002. In outer London and the rest of England, an estimated 69 per cent and 56 per cent of pregnant women respectively, had their infection diagnosed prior to delivery (Figure 13). However, because of the increasing prevalence, the number of HIV infected infants has not fallen. More than half of the children diagnosed with AIDS aged less than one year and born in 2000 were born in what have been regarded as low prevalence areas.

  5.22  Implications for GUM services: Although the uptake of antenatal screening in inner-London continues to exceed set targets, there are concerns regarding the provision of these services outside of London. Future GUM and HIV service provision must take into account the needs of these HIV infected children and families.

6.  IMPACT ON EXISTING GUM CLINIC SERVICES

  6.1  Recent increases in sexual behaviour, rapidly increasing STI and HIV diagnoses, coupled with the sexual health promotion and growing awareness of GUM services have lead to substantial increases over the past decade. Although services have largely coped with the increases, there is now growing evidence that GUM services are now over-stretched resulting in delayed access times and a failure to effectively control STI spread in the community.

  6.2  The delay in access time to curative service is important in STI transmission as this increases the duration of infectiousness (since the individual remains untreated for longer) and increases the probability of disease transmission (since infected individuals continue to have sexual intercourse).

Key point 10

Poor GUM clinic access is now widespread throughout England. The median time to first appointment in 2002 has lengthened to 12 days for men and 14 days for women.

  6.3  The total number of episodes seen in GUM clinics in the UK nearly doubled between 1990 and 1999, rising from 624,269 to 1,169,53731 (Figure 14). This rise has almost certainly contributed to the large increase in patient waiting times recently reported by GUM clinics. 32 If patients wait longer to get treated this may increase the likelihood of STIs being passed on to sexual partners and of the development if STI-related complications. 33, 34

  6.4  During 2002, the unprecedented demand for GU Medicine services has increased with a corresponding deterioration in patient access times, especially in London and other major conurbations. For most GUM clinics, the numbers of women attending exceeds that of men. Consequently appointment delays for women are longer because of their longer examination times

  6.5  Poor access is now widespread throughout England. The median time to first appointment in 2002 has lengthened to 12 days for men and 14 days for women, compared with five and six days respectively in 2000 when concern was first expressed. The majority of the 700,000 new attenders at GU Medicine clinics each year are having unacceptable delays for initial assessment and treatment. 35

  6.6  Poor access to curative services frustrates STI prevention and control. Persons at increased risk fail to obtain timely treatment and may continue to spread their STI. This is particularly worrisome in areas experiencing STI outbreaks (eg syphilis outbreaks in Manchester and London) or in hyperendemic areas (eg South London) since early and effective treatment of disease should be the primary goal of STI control.

  6.7  In the absence of any increase in GUM capacity, the problems of GUM clinic access are likely to worsen, not improve, given the current trends. It is also of concern that the government's Sexual Health and HIV Strategy proposes to introduce a range of HIV/STI prevention initiatives including Hepatitis B Screening, HIV testing promotion, and chlamydia screening. Taken in concert, these interventions will further increase pressures on overstretched services. Consequently, the benefits of screening and sexual health promotion are likely to be offset by the frustration and delays experienced by GUM clinic attenders and those providing curative services.

7.  CONCLUSIONS

  7.1  Sexual health in Britain is deteriorating as evidenced by the recent marked increases in bacterial and viral sexually transmitted infections, focal outbreaks of syphilis in metropolitan areas, and the increasing diagnoses of HIV infection, particularly among homosexual men and heterosexuals who may have acquired their infection abroad.

  7.2  Whilst increases in high-risk sexual behaviour are key determinants of this deterioration, other factors for example changes in health seeking behaviour, as well as true increases in the prevalence of disease in the community are also contributing to the observed increases in STIs.

  7.3  Placed in concert, the behavioural changes and increases in STIs have placed substantial pressures on the available Genitourinary Medicine Clinics. Evidence of this increased burden include: delays in GUM clinic access times (currently two to three weeks); increases in workload for GUM clinic and administrative staff.

  7.4  The impact of these increases have had a deleterious effect on service provision and have resulted in a vicious circle in which the increased workload increases staff stress; overstretched staff are leaving the service;

8.  RECOMMENDATIONS

  8.1  In view of the available evidence we recommend the following:

  8.2  Urgent investment into existing GUM services to reduce waiting times and improve access to STI screening, diagnosis and treatment. This has been identified as a priority area in the governments Sexual Health and HIV strategy, and must be implemented urgently. GUM clinic waiting times are increasing and many clinics, particularly those in worse affected areas, turn patients away on a daily basis. Planned initiatives outlined in the Sexual Health and HIV Strategy such as HIV testing promotion, chlamydia screening and Hepatitis B Screening will severely exacerbate the lack of GUM capacity due to the resultant increased demand. Shifting sexual health care into primary care is unlikely to adequately meet these increased needs given similar burdens on those services.

  8.3  Timely implementation of population based screening for genital chlamydia infection among young women. The government's proposals to implement a national screening programme for Chlamydia trachomatis infection are welcome, however, it is of utmost importance that this be implemented as quickly as possible. The DH funded Chlamydia Pilot Study has confirmed the feasibility and acceptability of opportunistic screening. In a context of increasing high-risk behaviours and rising STIs, such innovative interventions should be implemented without delay.

  8.4  Target interventions with population sub-groups vulnerable to sexual ill-health. Available surveillance and research data confirm significant inequalities in the distribution of STIs and HIV in the England and Wales. Young people, gay men and ethnic minorities in particular, appear to be at substantially increased risk of poor sexual health outcomes. Funds should be made available urgently to support innovative, evidence based and participatory prevention interventions with population sub-groups at increased risk.

  8.5  Tackle regional variations in sexual health outcomes. STI and HIV surveillance data confirm the disproportionate burden of STIs in "hot-spots"—socio-economically deprived, inner city areas in Britain. In such settings, STI rates are among the worst in Western Europe, rivaling levels seen in deprived areas in the US and some developing countries. Plans to roll-out sexual health provision outside of GUM clinic sector in these areas are unlikely to be successful as general practice services are also overstretched. We therefore recommend that consideration is given to increasing the capacity (ie increasing GUM clinic sessions, clinics etc.) in worse affected areas with the piloting and evaluation of innovative models of GUM service provision and partner notification.

  8.6  Sustain and improve HIV and STI surveillance. There is a need to maintain and enhance the surveillance effort as the HIV epidemic grows in size and complexity. We must maintain the ability to retain anonymised tissue specimens (in tissue which would otherwise be discarded) on the large scale necessary for the unlinked anonymous programme. The ability to evaluate and monitor the outcomes of prevention programmes at a national level also needs to be enhanced.


Table 1

END OF YEAR HIV PREVALENCE OF DIAGNOSED INFECTION IN RESIDENT ADULTS, ENGLAND, WALES AND NORTHERN IRELAND: 1996-2000 AND EXTRAPOLATIONS TO 2001-05*
Year1996 19971998 199920002001 20022003 20042005
MSM9,20210,489 11,43412,47313,309 14,44015,46016,480 17,50018,520
Hetero3,5024,406 5,3366,6208,154 9,06010,21011,360 12,52013,670
All other1,5021,534 1,6391,6511,553 1,6401,6701,690 1,7201,740
Total14,20616,429 18,41020,74523,017 25,14027,34029,530 31,74033,930


Table 2

ESTIMATED PREVALENT HIV INFECTIONS, DIAGNOSED AND UNDIAGNOSED, AMONG ADULTS* IN THE UK AT END OF 2000 (ROUNDED TO NEAREST 100)
Route of InfectionNumber Diagnosed Number Undiagnosed (percentage of total) Total
Sex between men13,800 3,200 (19%)17,000
Injecting drug use males and females  1,300    200 (13%)  1,500

male  3,300 3,100 (48%)  6,400
Sex between men and womenfemale   5,2002,900 (36%)   8,100
total  8,500 6,000 (41%)14,500

Blood products males and females   500     0   (0%)   500


Grand Total
24,100 9,400 (28%)33,500

9.  REFERENCES

  1  Johnson AM, Mercer CH, Erens B, Copas AJ, McManus S, Wellings K et al. Sexual behaviour in Britain: partnerships, practices, and HIV risk behaviours. Lancet 2001; 358(9296):1835-1842.

  2  Wellings K, Nanchahal K, Macdowall W, McManus S, Erens B, Mercer CH et al. Sexual behaviour in Britain: early heterosexual experience. Lancet 2001; 358(9296):1843-1850.

  3  Dodds J, Mercey D. Monitoring high risk sexual behaviour amongst gay men in London—2000. Royal Free and University College Medical School. London 2001.

  4  Hickson F, Reid D, Weatherburn P, Stephens M, Brown D. Time for more. Findings from the National Gay Men's Sex Survey 2000. Sigma Research, London, 2001.

  5  Elford J, Bolding G, Maguire M, Sherr L. Gay men, risk and relationships. AIDS 2001; 15(8):1053-1055.

  6  Elford J, Bolding G, Sherr L. Seeking sex on the internet and sexual risk behaviour among gay men using London gyms. AIDS 2001; 15(11):1409-1415.

  7  Holmes KK, Sparling PF, M-rdh P-A et al. editors. Sexually Transmitted Diseases. 3rd ed. USA: McGraw-Hill; 1999.

  8  PHLS, DHSS&PS and the Scottish ISD (D) 5 Collaborative Group. Sexually Transmitted Infections in the UK: New Episodes seen at Genitourinary Medicine Clinics, 1995-00. 2001. London, Public Health Laboratory Service.

  9  Public Health Laboratory Service, Communicable Disease Surveillance Centre. Unpublished data.

  10  PHLS, DHSS&PS and the Scottish ISD (D) 5 Collaborative Group. Sexually Transmitted Infections in the UK: New Episodes seen at Genitourinary Medicine Clinics, 1995-00. 2001. London, Public Health Laboratory Service.

  11  Nicoll A, Hughes G, Donnelly M, Livingstone S, De-Angelis D, Fenton K, et al. Assessing the impact of national anti-HIV sexual health campaigns: trends in the transmission of HIV and other sexually transmitted infections in England. Sex Transm Infect 2001; 77:242-247.

  12  Pimenta JM, Catchpole M, Rogers PA, Perkins E, Jackson N, Carlisle C, Randall S, Hopwood J, Hewitt G, Underhill G, Mallinson H, McLean L, Gleave T, Tobin J, Harindra V, Ghosh A. Opportunistic screening for genital chlamydial infection I: Acceptability of urine testing in primary and secondary health care settings. Submitted to Sex Transm Infect

  13  Pimenta JM, Catchpole M, Rogers PA, Hopwood J, Randall S, Mallinson H, Perkins E, Jackson N, Carlisle C, Hewitt G, Underhill G, Gleave T, McLean L, Ghosh A, Tobin J, Harindra V. Opportunistic screening for genital chlamydial infection II: Prevalence among health care attenders, outcome and evaluation of positive cases. Submitted to Sex Transm Infect

  14  PHLS, DHSS&PS and the Scottish ISD (D) 5 Collaborative Group. Sexually Transmitted Infections in the UK: New Episodes seen at Genitourinary Medicine Clinics, 1995-00. 2001. London, Public Health Laboratory Service.

  15  PHLS, DHSS&PS and the Scottish ISD (D) 5 Collaborative Group. Sexually Transmitted Infections in the UK: New Episodes seen at Genitourinary Medicine Clinics, 1995-00. 2001. London, Public Health Laboratory Service.

  16  Hughes G, Nichols T, Rogers P, Kinghorn G, Mercey D, Thin N. Re-infection with gonorrhoea: analysis of risk factors from a retrospective cohort study. MSSVD /SSGM Spring Meeting. Oslo, Norway, 15-18 May 2002.

  17  PHLS, DHSS&PS and the Scottish ISD (D) 5 Collaborative Group. Sexually Transmitted Infections in the UK: New Episodes seen at Genitourinary Medicine Clinics, 1995-00. 2001. London, Public Health Laboratory Service.

  18  Public Health Laboratory Service Communicable Disease Surveillance Centre. Unpublished Data.

  19  PHLS, DHSS&PS and the Scottish ISD (D) 5 Collaborative Group. Sexually Transmitted Infections in the UK: New Episodes seen at Genitourinary Medicine Clinics, 1995 to 2000. 2001. London, Public Health Laboratory Service.

  20  Low N, Daker-White G, Barlow D, Pozniak A. Gonorrhoea in inner London: results of a cross sectional study. BMJ 1997;314:1719-1723.

  21  Lacey C, Merrick D, Bensley D, Fairley I. Analysis of the sociodemography of gonorrhoea in Leeds, 1989-93. BMJ 1997;314:1715-1718.

  22  Hughes G, Andrews N, Catchpole M, Goldman M, Forsyth-Benson D, Bond M, et al. Investigation of the increased incidence of gonorrhoea diagnosed in genitourinary medicine clinics in England, 1994-96. Sex Transm Infect 2000;76:18-24.

  23  Hickman M, Judd A, Maguire H, Hay P, Charlett A, Catchpole M, et al. Incidence of gonorrhoea diagnosed in GUM clinics in South Thames (West) Region. Sex Transm Infect 1999;75:306-311.

  24  Low N, Daker-White G, Barlow D, Pozniak A. Gonorrhoea in inner London: results of a cross sectional study. BMJ 1997;314:1719-1723.

  25  Hughes G, Brady A, Catchpole MA, Fenton KA, Rogers PA, Kinghorn GR, et al. Characteristics of those who repeatedly acquire sexually transmitted infections: a retrospective cohort study of attendees at three urban sexually transmitted disease clinics in England. Sex Transm Dis 2001;28:379-386.

  26  Lear D. Sexual communication in the age of AIDS: the construction of risk and trust among young adults. Soc Sci Med 1995;41:1311-1323.

  27  Adib SM, Joseph JG, Ostrow DG, James SA. Predictors of relapse in sexual practices among homosexual men. AIDS Educ Prev 1991;3:293-304.

  28  Hughes G, Brady A, Catchpole MA, Fenton KA, Rogers PA, Kinghorn GR, et al. Characteristics of those who repeatedly acquire sexually transmitted infections: a retrospective cohort study of attendees at three urban sexually transmitted disease clinics in England. Sex Transm Dis 2001;28:379-386.

  29  Rogstad K, Clementson C, Ahmed-Jushuf I. Success of partner notification in heterosexuals with gonorrhoea: effects of sex and ethnicity. Sex Transm Inf 1998;74:379

  30  Hook III E, Richey C, Leone P, Bolan G, Spalding C, Henry K, et al. Delayed Presentation to Clinics for Sexually Transmitted Diseases by Symptomatic Patients. Sex Trans Dis 1997;24:443-448.

  31  PHLS, DHSS & PS and the Scottish ISD (D) 5 Collaborative Group. Trends in Sexually Transmitted Infections in the United Kingdom, 1990-99. 2000. London, Public Health Laboratory Service.

  32  NHS Health Development Agency Website. http://www.hda-online.org.uk/html/hdt1101/sexualhealth.html.

  33  Djuretic T, Catchpole M, Bingham JS, Robinson A, Hughes G, Kinghorn G. Genitourinary medicine services in the United Kingdom are failing to meet current demand. Int J of STD & AIDS 2001;12:571-572.

  34  Hook III E, Richey C, Leone P, Bolan G, Spalding C, Henry K, et al. Delayed Presentation to Clinics for Sexually Transmitted Diseases by Symptomatic Patients. Sex Trans Dis 1997;24:443-448.

  35  Informal communication. Dr. George Kinghorn. MSSVD Past President.





 
previous page contents next page

House of Commons home page Parliament home page House of Lords home page search page enquiries index

© Parliamentary copyright 2002
Prepared 27 August 2002