Select Committee on Science and Technology Fourth Report


3  THE FORWARD INVESTMENT STRATEGY

Origins

12. The underlying justification for any review of NIMR has been consistently questioned and criticised throughout the current process and during the course of our inquiry so we went back to its origins to gain a fuller understanding of the background. The MRC Council set up the Forward Investment Strategy (FIS) Subcommittee in October 2002 to develop a coherent long-term strategy for its major capital investments over the following 10-15 year period. The Committee was chaired by the former Chief Executive Officer (CEO), Sir George Radda, and consisted of eight academic, health services and industry representatives. It looked at strategic planning at four sites which faced strategic decisions over the ensuing few years: the MRC units based at Harwell, where the DIAMOND synchrotron is due to open in 2006; the Clinical Research Centre (CRC) at the Hammersmith Hospital Campus of Imperial College; the Laboratory of Molecular Biology (LMB) and other units at the Addenbrooke's hospital site; and NIMR at Mill Hill.[20]

13. The original rationale for the FIS review was challenged by the Director of NIMR, Sir John Skehel, in the course of our inquiry. He suggested that there was a desire at MRC to relocate NIMR even before the establishment of the FIS review. In supplementary and confidential evidence to us he alleges that the original intention, circulated by MRC in a draft paper in August 2002, was for there to be a review only of NIMR. This paper "seeks the Council's views on a framework for reviewing the future of the National Institute for Medical research (NIMR) in the context of the retirement of the current Director, Sir John Skehel, in 2006", and considered the principles relevant to its consideration and the timetable for a decision process.[21] The paper identifies as the central issue of the review the maintenance of NIMR at Mill Hill in its present form set against the consideration of "other options in terms of location and/or structure". It envisaged the commissioning of senior independent academic advisers to consult widely with NIMR and to produce a report to inform further discussions in Council. This would have preceded any public debate of the institute's future.[22]

14. Sir John Skehel states that in his discussions with the MRC Chairman, Sir Anthony Cleaver, on this issue the poor state of the buildings at Mill Hill was also cited as a reason for the review.[23] Following Sir John's subsequent complaints to the Chairman and arguments about the health of the buildings, this first draft paper was withdrawn. The MRC Chairman wrote (in confidence) to Sir John to tell him that his concerns were understood, "in particular the consultation procedure that was proposed, could be read as prejudging the outcome […] we have therefore decided to take a step back and start by setting up a Council sub-committee with a broader remit to consider forward investment strategy [the FIS sub-committee]".[24] The revised paper proposed that a Council Subcommittee be established to look at the other major MRC institutes as well in order to present a long term strategy for major capital investment in time for the 2004 Spending Review.[25] It specified the retirement of Sir John Skehel in 2006 in its terms of reference. It envisaged that the Subcommittee would review stakeholder input before finalising its report.

15. We have seen the relevant draft MRC papers, the first of which was apparently not circulated to the Council, as well as the confidential exchange of letters between Sir John Skehel and Sir Anthony Cleaver. We put Sir John's allegation of a change of emphasis to the FIS committee members from whom we took evidence. Professor Rothwell told us that the issue of the long term future of NIMR was raised in Council papers in 2000, as was the future of other institutes. She said that "to suggest that there was something there and then it changed is not quite the right interpretation of that. I can see that you could put that interpretation on it, but I think you have to look at each institute's long term future. The idea then was to bring it together into one group".[26] Given the confidential nature of the exchanges between the Chairman and Sir John Skehel, we would not necessarily expect all Council members to be aware of the precise details of the evolution of the FIS Subcommittee. Professor North confirmed that he had seen nothing of any proposals which preceded the establishment of the FIS Subcommittee.[27]

16. Given that the retirement of the Director in 2006 was highlighted as a justification for the FIS review in the proposal for its establishment we were interested to hear from witnesses on the FIS committee that Sir John's retirement did not play a strong role in their considerations.[28] We questioned why the change of Director necessitated a review of the NIMR. Sir John Skehel argued that it is normal practice to review the future of a unit when its Director leaves but not that of a multi-disciplinary institute. At NIMR it is not the scientific leader of each division or unit who is retiring.[29] We understand that there have been reviews of the institute's future prior to the recruitment of previous Directors. We accept that the role of the Director is extremely important to the management, reputation and well-being of an institute. However, we consider that, whilst the direction of a smaller unit may generally be strongly influenced by the head of it, in a large institute with several divisions, many disciplines and specialist scientists, the individual scientific strengths of the director are not always so important. We agree that a change of Director of a national institute should not necessarily in itself require a strategic change for the institute if it is performing well, nor should a change of direction be impossible to achieve with the same Director. Taken together with other factors, such as a change in focus of medical research, there might well be a case for fundamental review, but the reasons for any review should be spelled out clearly from the outset.

17. Sir John told us that what he calls the "shifting rationale" of the basis for the review and the close proximity of the FIS review to the quinquennial review "certainly influenced how the Institute received the FIS proposals".[30] It is difficult to ascertain at this distance the precise motivation for the FIS review and to judge whether there was a preconception about the state of the buildings at Mill Hill. In this context, we were disappointed that the Chief Executive at the time, Sir George Radda, declined our invitation to submit written evidence on this point on the grounds that he no longer held records of discussions of these matters.[31]

18. We fully support the need for long term strategic reviews of investment to complement the science-orientated programme of quinquennial reviews. In our Reports on the Research Councils, we have consistently supported the policy of regular and stringent reviews of institutes established and supported by the Councils. We believe that there was a strong case for a review of MRC's long term investment strategy and that MRC was doing its job in seeking to match its future investment needs with the priorities it set out in it's A Vision for the Future strategy, itself the result of consultation with stakeholders. It was right to ask the question as to whether the £27 million it was spending per annum on the NIMR would be more productively spent in another way. However, the reasons for taking a long term look at the direction and viability of NIMR at Mill Hill were not presented in a coherent or convincing way to NIMR staff or the wider community. The initial proposal for the FIS review made no reference to the simultaneous strategic science review. MRC was right to broaden any initial focus on NIMR to include other facilities, but the consequence was that management at NIMR gained the impression that the focus was really on Mill Hill and, rightly or wrongly, confidence in the ensuing process of review was damaged at the outset.

Work of the Forward Investment Strategy Subcommittee

19. The FIS Subcommittee met four times before presenting its report to the MRC Council in March 2003. In developing its proposals, the FIS Committee took as its "primary scientific reference point" MRC's ten year strategy, A Vision for the Future. It then developed a template for optimal medical research environments to deliver international excellence over the next 10-15 years, based on the following principles:

Consideration of the options

20. The FIS Committee concluded that, when assessed against this template, the case for maintaining Mill Hill on its present site was "not strong".[33] It gave two reasons:

NIMR at its present location may be too isolated from clinical and other academic units to compete and remain as attractive to scientists; and

The cost of maintaining the institute would have significant implications for MRC's future financial flexibility.

21. Future research environments had to present significant opportunities for multi-disciplinary work, strong clinical and academic links and opportunities for translating research into the health service and the commercial sector.[34] It concluded that "in terms of opportunity cost, a new smaller investment in a clinical multi-disciplinary environment for the Institute would be likely to deliver a similar volume of science and greater value for money in the longer-term".[35] It recommended that the future scientific programme of NIMR should be developed on a university/medical school site at Addenbrooke's in Cambridge.

22. The FIS report is important to the current proposals because it enunciated the principles upon which the Task Force was asked to build in its consideration of a broader range of options. In our view the report from the FIS committee does not provide convincing evidence that it explored all aspects of its remit with the vigour necessary to back up its conclusions. The FIS committee did not appear to question in detail the principle that interaction is necessarily improved by physical proximity. The written evidence that we received was very divided on this point: some, including Professor Rothwell, took the view that interaction between clinician and scientist must be easier if they are both based on the same site.[36] Others argued that co-location could often lead to "a dilution of focused effort"[37] and that "translation is largely an intellectual process that transcends distances".[38] We recognise that the arguments are complex and deserve thorough exploration in order to see if a consensus can be established. Instead, it seems to us that the FIS committee took as its starting point its perception of an ideal research environment, as derived from the MRC ten year strategy, and did not question it. Given this template, and the principles on which the committee based its work, it was inevitable that the Mill Hill site would not match up to the ideal environment for medical research, with its focus on clinical/academic links. Professor Rothwell confirmed that it would be "very difficult" for it to meet this template.[39] The FIS committee did not explore thoroughly the scenario whereby institutions could retain independence whilst having the flexibility to pursue their own relationships with multiple clinical centres of their choice. We have not re-examined all the pros and cons of the principle of co-location in great detail: the Task Force undertook this difficult job. We would hope, however, that the argument put forward by Professor North that Mill Hill was "physically becoming isolated" was, given the progress of modern communication technology, at least thoroughly explored by the FIS committee before it reached its conclusions.

23. The issue of value for money was one which might have been expected to be considered closely by the committee, given that one of the drivers behind the FIS process was to meet OST's demands for better long term capital investment planning over a 15 year period and to underpin a bid for the 2004 Spending Review. As we have mentioned, the FIS committee concluded that one of the reasons for proposing a move from the Mill Hill site was that the likely investment required for NIMR to remain viable at Mill Hill had "significant financial implications for MRC's future financial flexibility" and that "a new smaller investment in a clinical multi-disciplinary environment would be likely to deliver a similar volume of science and greater value for money in the longer term".[40] There is no evidence adduced in the report to support these conclusions. We were told that there was an assumption in the FIS committee that London might be more expensive[41]—not an argument that the Task Force found persuasive—but we saw no supporting evidence or research to back up this assumption. The level of investment required to maintain the buildings at Mill Hill was later the subject of some dispute in the Task Force and did not seem to be the subject of an informed estimate by the FIS committee.[42] Given the conclusion referred to above about value for money, we were surprised to hear from FIS Subcommittee members that costs were not considered "in any detail at all".[43] Professor North told us that it would be difficult to envisage a cost benefit analysis projecting forward for 15-20 years.[44] There was some discussion of the potential of co-located institutes to share infrastructure costs but "no detailed financial considerations".[45] Witnesses explained that the primary driver was scientific value and getting the best research.[46]

24. Like other Research Councils, MRC has a responsibility to delivering the best science it can using the resources made available to it. No research funding council can sensibly divorce its consideration of the different options for delivering its science from the costs of each one. There may have been a case for the move to Addenbrooke's based on the reinvestment of the revenue accruing from the sale of the Mill Hill site at a different location or locations. But such a case was not set out in the proposals. Cost should not necessarily be the driving force behind change in any review of investment in science but it has to at least be carefully considered. We were told by members of the committee on the Forward Investment Strategy that their work was "not about money", and yet cost was one of the two reasons given for its conclusions. It is regrettable that confusion over the justification for the conclusions of the FIS review was allowed to develop.

25. Similarly, we are not persuaded that the recommendation of a move to Addenbrooke's was thoroughly thought through. In the FIS committee's report, the suggestion is made right at the end in the context of investment at Addenbrooke's. There is no indication that other locations outside the golden triangle between London, Oxford and Cambridge were considered, or that the implications for existing staff at NIMR were considered. This was a major omission, given that the Task Force subsequently concluded that the importance of maintaining a critical mass of existing scientists at NIMR was such that a move away from London could not be considered. Professor Rothwell told us that London was considered but was thought to be too expensive.[47] She made a distinction between the FIS report, which put ideas down for consultation, and the work of the Task Force, which carried out "a much more detailed in-depth analysis".[48] We accept this distinction but it shows that MRC were prepared to put forward firm proposals without conducting the in-depth analysis necessary to justify and explain them. Our concerns about the superficiality of the FIS process were reinforced by Professor North, who told us that it was "difficult to proceed" on the basis of the evidence.[49] He argued that science would not progress very quickly if evidence was needed to be produced to support any change to the status quo. The break-up of a world renowned national institute and relocation elsewhere is a risky strategy. It should not be proposed without the most careful consideration and assessment of all the costs and benefits. The FIS Subcommittee report did not provide the level of detailed consideration that was required to support such a radical proposal.

26. It could be argued that the FIS report was only a consultation document. At the time, the MRC Council described it as a "valuable starting point for discussion with a wide range of stakeholders—this consultation is therefore the start of an ongoing dialogue. MRC Council intends that the report, and the discussions which now follow, will provide a template for more detailed planning to be developed at the four sites, as well as a backdrop for discussions on future partnership opportunities at other sites".[50] Although ostensibly for discussion, the report's tone suggested that the consultation was not to be on the necessity of a move, but on the details of negotiation with potential partners. For some, it had an air of certainty about it which proved difficult for MRC to dispel until the proposals were withdrawn following the consultation exercise.

27. The remit of the FIS Subcommittee was focussed very specifically on investment at four sites. This did not allow the committee to consider the relationship between MRC policy in taking forward its strategic goals with investment at these sites. We repeatedly asked MRC what other methods of achieving its goals of increasing its focus on translational and multi-disciplinary research were considered, apart from the move of NIMR. For example, the MRC could have explored the potential for reorganising its funding to establish new research units in hospitals; or for altering its criteria for awarding research grants; or for refocusing of the aims of other institutes, such as the Laboratory for Molecular Biology. Asked whether MRC had put as much effort into considering these other possibilities as it had into investment in institutes, Professor Rothwell said that "I think it probably has in different ways",[51] but MRC did not provide us with any evidence to support this. In answer to our specific question MRC replied as follows: "The increasing emphasis on translational approaches, in MRC as in most medical research funding agencies in the UK and around the world, gathered momentum in 2002-03 and was articulated in the MRC 10-year Vision published in 2003 following stakeholder consultation. The strategy has had and will continue to have implications across the MRC portfolio, not just at NIMR."[52] We find it surprising that MRC is unable to say what these implications might be. They were certainly not considered by the FIS Subcommittee. Indeed, the proposal for the establishment of the FIS Subcommittee made no reference to the strategic review which was the subject of consultation at the same time. Witnesses told us that the Subcommittee's focus was on the future of NIMR rather than the wider picture of the role of the institute in the reorientation of MRC's strategy. They did not discuss this latter issue at all. We were told that it was for other committees to consider policy relating to grant awards.[53]

28. The MRC has a range of policy levers it can use to implement its vision for the future but each has an impact on the others and they need to be used in a co-ordinated way. The review of its physical infrastructure is one such lever, but it appears to have been considered in isolation. There seems to have been a recognition at MRC that the ten year strategy would have an undefined impact on policy. However, MRC would not constitute a coherent attempt to devise a set of policies which, taken together, would ensure that the strategy was implemented. By asking the FIS committee to focus only on how its facilities might best meet the vision it has established, MRC fuelled concerns in the minds of some there was a preconceived agenda in relation to Mill Hill. More importantly, it did not given the impression that it was taking a holistic and comprehensive approach to realising the vision of the future that it had agreed with its stakeholders.

Relationship with Quinquennial Review

29. The 2000 quinquennial review of NIMR is cited by many of those opposed to the move of NIMR as evidence that the institute was performing well: the review recommended no strategic shift in its research. The Director of NIMR refers to the last review and states that he recalls no discussion at the time on the need for any additional review.[54] In its evidence, MRC points to a distinction between the focus of the quinquennial reviews on research strategy and quality for the following five years and the demand for a strategic review of capital investment for the longer term. It also states that the strategic review was needed well in advance of the retirement of the Director in 2006. It describes the ongoing review of NIMR as part of the MRC's "normal approach to forward planning and strategic review of its intra-mural investment".[55] Professor Denton, a member of the Task Force, suggested that quinquennial reviews were "not the perfect vehicle for tackling strategic longer-term considerations" and argued that a review of the mission, site and size of major institutes every twenty years was vital.[56] Professor Rothwell told us that quinquennial reviews often look at long-term infrastructure issues, although not in detail, and noted that the 2000 review of NIMR raised some specific concerns on this front.[57]

30. It was clear from the evidence we received that the proposals for NIMR to move were viewed in many quarters as an implicit or indirect attack on the quality of science there. The vast majority of the submissions we received commented on the high quality of the science conducted at Mill Hill; only three raised any criticisms.[58] In evidence, MRC witnesses told us that the reviews were not about the quality of science.[59] Professor Blakemore's private view was given in an email to Professor Tomlinson in March 2004 in support of his argument for a federated option in London for NIMR. He said: "Mill Hill has lost its edge. The work there is good, but not consistently world-class. It's not as good as LMB [Laboratory of Molecular Biology], yet its "mission", to the extent that it has one, is very similar to that of LMB. So, it's hard to justify continuation of the huge slice that it takes from MRC funds without a reorientation in a way that defines a distinct scientific mission and that makes it more effective as a NATIONAL facility".[60] Witnesses from the FIS committee confirmed that their job was not to judge the quality of the science there and that this message was repeatedly put across to staff at NIMR.[61] Whether this message got through to staff there and the wider medical research community is open to doubt. We have gained the impression that staff there felt under threat from the start, rather than being engaged in an exciting process of renewal of their valued institute. The perception that the work of NIMR was under attack by the FIS process was allowed to build up. The inability of MRC to convince the staff at Mill Hill that it valued the work conducted there contributed to the deterioration in relations that was to occur over the ensuing months and represents a regrettable management failure.

Engagement with NIMR

31. There have been suggestions that NIMR did not engage fully with the FIS process as it continued and thus that the proposals that emerged came as something of a shock. MRC's evidence states that the principles on which the FIS committee based its work were agreed at its first meeting in November 2002, after which the Directors of the Institutes affected were invited to discuss them with the committee. The FIS committee had a meeting with NIMR staff and with the Director before developing its detailed proposals which were published in April 2003. It is not clear how far the nature of the proposals under development was discussed at this meeting, but NIMR reports that until 31 March 2003 "we were unaware of any proposal to relocate NIMR and, therefore, had not engaged in the development of this proposal".[62]

32. Each of the Directors affected by the FIS report was sent an advance copy of the report on 31 March, with visits by MRC management planned for the following day—two days before publication—to explain and consult. The MRC evidence states that "in the event, the Director chose to circulate the report to all staff at NIMR in advance of the meeting. Heads of Division walked out of the meeting without any engagement. Subsequent engagement with staff, including some meetings between NIMR scientists and FIS members, demonstrated that resistance to the FIS propositions was implacable and led to the decision to take a different approach to engaging NIMR staff in discussions in the Task Force".[63] The NIMR evidence states that the Heads of Division walked out of the meeting when the MRC Chairman "failed to reassure the Heads of Division of the possibility of reversing the FIS recommendation by consultation".[64] Subsequently, NIMR reports that it participated fully in the consultation process.

33. Professor Blakemore's experience was somewhat different. In the visits to Mill Hill that he made in order to meet staff before he took up his position he noted the "unwillingness of Sir John and senior staff to engage with the MRC".[65] Members of the FIS committee told us that there was engagement with staff at NIMR, for example, on visits to Mill Hill, but acknowledged that the Director was not consulted until near the end of the process.[66] Professor North, a member of the FIS committee, told us that when the committee visited NIMR around the time of the publication of the proposals "there did seem to be a perception around that minds had been made up" in spite of committee members' assurances that this was a draft for consultation.[67]

34. The FIS committee did consider whether to give the institutes involved more information about its developing views before publishing the consultation paper but decided against it. Professor Rothwell thought that this would have been more destabilising and "even more damaging".[68] Even in hindsight, she was not convinced that this would have been a better option. We disagree. Earlier informal discussion with NIMR staff may have given the FIS committee some indication of the pitfalls of their proposals which were brought out in the subsequent consultation process and were serious enough to cause MRC to withdraw the proposals.

Conclusion on FIS process

35. We have already discussed how the different rationales cited for the FIS process may have cast doubt on its integrity in the minds of some at the outset. Even without such doubts, it is essential for any organisation contemplating radical change to engage with those affected from the start in order to persuade them of the case for change and to maintain the morale of the workforce. MRC failed to do this adequately in the case of the FIS Subcommittee and thus passed up the chance to work with NIMR to effect change in a consensual manner. Greater engagement throughout its work may have fostered a more co-operative attitude at NIMR from the start, although there is evidence to suggest that some staff there were intent upon resistance, whatever the merits of the case. By seeming to impose change on a surprised and unconvinced work force, MRC lost the confidence of the staff of its largest institute. This in turn coloured the attitude of NIMR to the future efforts of MRC to consider the issue afresh and contributed significantly to the increasing fragility of their relationship.


20   MRC, Forward Investment Strategy, April 2003 Back

21   Not printed Back

22   Not printed Back

23   Ev 180 Back

24   Not printed Back

25   Ev 179 Back

26   Q 228 Back

27   Q 229 Back

28   Qs 247, 252 Back

29   Ev 179 Back

30   Ev 179 Back

31   Letter to the Clerk from Sir George Radda; not printed. Back

32   FIS Report, http://www.mrc.ac.uk/index/about/about-organisation/about-bodies_and_members/pdf-fis_consultation.pdf-link, paras 1.3 and 3.4 Back

33   FIS Report, http://www.mrc.ac.uk/index/about/about-organisation/about-bodies_and_members/pdf-fis_consultation.pdf-link, para 1.7 Back

34   FIS Report, http://www.mrc.ac.uk/index/about/about-organisation/about-bodies_and_members/pdf-fis_consultation.pdf-link, para 3.3 Back

35   FIS Report, http://www.mrc.ac.uk/index/about/about-organisation/about-bodies_and_members/pdf-fis_consultation.pdf-link, para 4b.4 Back

36   Ev 79; Q 211 [Rothwell] Back

37   Ev 59  Back

38   Ev 102 Back

39   Qs 205-7 Back

40   FIS Report, http://www.mrc.ac.uk/index/about/about-organisation/about-bodies_and_members/pdf-fis_consultation.pdf-link, para 4b.4 Back

41   Q 221 [Rothwell] Back

42   See para 24 Back

43   Q 209 [Rothwell] Back

44   Q 209 [North] Back

45   Q 236 Back

46   Q 233 Back

47   Q 221 Back

48   Q 221 Back

49   Q 210  Back

50   FIS Report, http://www.mrc.ac.uk/index/about/about-organisation/about-bodies_and_members/pdf-fis_consultation.pdf-link, para 2.3 Back

51   Q 219 Back

52   Ev 172, Q5 Back

53   Qs 215-6 Back

54   Ev 178 Back

55   Ev 50 Back

56   Ev 172 Back

57   Q 241 Back

58   Ev 85, 86, 99 Back

59   Qs 24-8 Back

60   Ev 225  Back

61   Q 241-2 Back

62   Ev 175 Back

63   Ev 173 Back

64   Ev 176 Back

65   Ev 215 Back

66   Q 195 [Rothwell] Back

67   Q 198  Back

68   Qs 195 [Rothwell], 202 Back


 
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