Annex C
Curriculum Vitae: Sir Tom Blundell FRS, FMedSci
Chair of School of Biological Sciences and Sir William
Dunn Professor of Biochemistry,
Department of Biochemistry, University of Cambridge,
Date of Birth: 7th July 1942. Place of Birth: Brighton,
Sussex.
1. Academic
| 1961 | Open Scholarship in Natural Sciences, Brasenose College, Oxford University.
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| 1964 | First Class Honours, Brasenose College, Oxford University.
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| 1967 | D.Phil., Oxford University.
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| 1967 | College Lecturer, Hertford College, Oxford University.
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| 1968 | Junior Research Fellow Molecular Biophysics. Linacre College, Oxford
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| 1973 | Lecturer, Biological Sciences, Sussex University.
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| 1976 | Professor, Department of Crystallography, Birkbeck College, University of London
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| 1989 | Director, Imperial Cancer Research Fund Unit of Structural Molecular Biology
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| 1991 | Director General, Agricultural and Food Research Council
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| 1994 | Chief Executive, BBSRC (till 1996)
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| 1995 | Sir William Dunn Professor of Biochemistry, University of Cambridge.
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| 1996 | Head of Department of Biochemistry, University of Cambridge (until 2009)
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| 2003 | Chair, School of Biological Sciences. Cambridge (until 2009)
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| 2009 | Director of Research and Emeritus Professor, Department of Biochemistry
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2. Honours
| 1984 | Fellow of the Royal Society
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| 1985 | Member of EMBO |
| 1986 | Alcon Award for Distinguished Work on Vision esearch
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| 1987 | Gold Medal, Institute Biotechnology: Krebs Medal, Fed. Eur. Biochem. Soc.
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| 1988 | Ciba Medal, Biochemical Society; Feldberg Prize in Biology and Medicine
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| 1993 | Member Academia Europaea
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| 1995 | Fellow, Indian National Science Academy;
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| 1995 | UK National Equal Opportunities Award (for work in BBSRC)
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| 1996 | Gold Medal, Society for Chemical Industry
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| 1997 | Knighthood |
| 1998 | First Recipient, Pfizer European Prize for Innovation
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| 1998 | Bernal Medal and Lecture, Royal Society
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| 1999 | Founding Member, Academy of Medical Sciences
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| 2006 | honorary Member, British Biophysical Society; Honorary Fellow of Royal Society of Chemistry
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| 2008 | Associate Fellow, Academy of Third World Science
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3. Honorary Fellowships and Degrees
Honorary Fellowships, Brasenose and Linacre Colleges, Oxford University;
Honorary Fellowship, Birkbeck College, London University:
Honorary Doctorates from 14 Universities
4. Sidney Sussex College
- 1995 Professorial Fellow, Sidney Sussex College. Cambridge
University
- Development Committee. Finance Committee, Honorary fellowships
Committee
5. Research Interests
I have an active research group of twenty five post-doctoral researchers,
post-graduate students and technical/computer staff funded by
Wellcome Trust, Gates. BBSRC, MRC and industry (total grants in
past 9 years in excess of £5 million). I have published over
400 research papers (over 30 in Nature and Science). My research
interests are in the definition of the architecture of macromolecules
and their assemblies and the relation to biological function and
diseases including cancer, Techniques used in my laboratory include
biochemistry, protein crystallography and bio-computing. I have
used X-ray crystallography to define structures of multiprotein
complexes involved in DNA repair, including BRCA2 and mutations
that occur in breast and other cancers, Conformations of polypeptide
hormones, growth factors and their receptors, including work on
insulin, glucagon, pancreatic polypeptide, oxvtocin, nerve growth
factor, hepatocyte growth factor and fibroblast growth factor
complex with its receptor architecture of cellular signalling
systems such as protein kinases and their complexes that transduce
the intracellular response to growth factors and hormones. These
interests have led to work on rational approaches to drug design,
I have pioneered methods of structure-based design in 1970s, 1980"s
and early 1990's. In the past decade I have developed high throughput
and fragment-based approaches to drug discovery and co-founded
a successful company Astex. I have also produced extensive bioinformatics
software that is used throughout the world.
6. Editorial Boards
- Joint editor, Progress in Biophysics and Molecular Biology,
1979
- Joint editor, Current Opinion in Structural Biology, 1995-
- Editorial Boards: Biochemistry 1988-1994: Protein Engineering,
1988-; Protein Science, 1990-1996: Molecular Medicine, 1994-1998.
7. Industry: companies founded, boards etc
- Astex Technology Ltd: Co-founder, 1999, Board Member, 1999-,
Chairman of Science Advisory Board, 2000
- Biofabrika: Co-founder, 1989 - 1991
- Celltech: Consultant, 1980-1983; Non-executive Director. 1996-2004
; Chairman of Scientific Advisory Board, 1998-2004
- UCB Celltech, Science Advisory Board, 2005 -
- SmithKline Beecham: International R&D Board, 1997-1999,
Pfizer: Consultant in UK and USA, 1983-1990, Parke Davis: US Consultant,
1987-1990, Oxford Molecular Group: Scientific Advisory Board,
1996-1998, Bioprocessing: Chairman of Scientific Advisory Board,
1996-1998
- Abingworth Management Ltd. Science Advisory Board, 1986-1990,
1996
8. Research Councils
- Member of Council of Science and Engineering Research Council
(1998-2000) and of Agricultural and Food Research Council (1985-1990)
- Director General. Agricultural and Food Research Council (1991-1994):
responsible for implementing rationalisation of institutes.
- Founding CEO, Biotechnology and Biological Sciences Research
Council, 1994-1996.
9. Royal Commission on Environmental Pollution
Chairman of the Royal Commission on Environmental Pollution (1998-2005),
publishing reports on" Energy—the Changing Climate"
in 2000, which introduced the idea of 60% reductions in carbon
dioxide emissions, incorporated in the UK Governments White Paper
on Energy in 2003; "Chemicals in Products", "Environmental
Planning", "Turning the Tide—the Marine Environment"
and "Impacts of Civil Aviation on Global Warming".
10. Other Appointments and interests
- President, Biochemical Society, 01 January 2009
- President, UK Biosciences Federation (01/04-4/08):UK umbrella
organisation for life sciences, 70,000members.
- European Science and Technology Assembly, 1994-1997
- HFSP Council, 1996-1999
11. Government and other appointments
- Advisory Council on Science and Technology, Cabinet Office
(ACOST) 1988-1990
- Council of Royal Society. 1997-1999
- Member of Board, Parliamentary Office of Science and Technology,
1997-2006
- Trustee, Daphne Jackson Trust. 1995- ;
- Lawes Agricultural -trust, 1998
- Member, Board, Babraham Institute, 1996-2002
12. Personal
In my spare time I enjoy walking in Wales, listening to opera,
playing jazz and international travel. I am married to Dr Bancinyane
L Sibanda and have three children.
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